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| ID | Type | Description | Link |
|---|---|---|---|
| D-74 |
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| Name | Class |
|---|---|
| Anjo A/S | UNKNOWN |
The objective of this intervention study is to examine the effect of whole cow's milk versus infant formula as primary milk sources with or without supplements of n-3 LCPUFA for growth, nutritional status, development, risk factors for later diseases and the impact on the intestinal microbiota and inflammation in 9 - 12 months old infants.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cow's milk with fish oil | Behavioral | |||
| Cow's milk without fish oil | Behavioral | |||
| Formula with fish oil | Behavioral | |||
| Formula without fish oil | Behavioral |
| Measure | Description | Time Frame |
|---|---|---|
| Growth | ||
| Body composition (weight, length, knee-heel-length, waist, head, and arm circumference, skin fold measurements). | ||
| IGF-I | ||
| IGFBP-3 | ||
| Insulin - glucose metabolism (HOMA index). | ||
| Urea Nitrogen | ||
| Albumin | ||
| C-peptide | ||
| Amino Acids | ||
| Erythrocyte fatty acid composition | ||
| Blood pressure | ||
| Lipid Profile | ||
| Heart Rate Variability (HRV) |
| Measure | Description | Time Frame |
|---|---|---|
| Plasma concentrations of cholesterol and triglycerides | ||
| Allergy status | ||
| Cognitive test ("The infant means-end problem solving test") |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kim F Michaelsen, Dr Med Sci | Institute of Human Nutrition, Rolighedsvej 30, DK-1958 Frederiksberg C, Denmark | Study Chair |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18679165 | Result | Lauritzen L, Christensen JH, Damsgaard CT, Michaelsen KF. The effect of fish oil supplementation on heart rate in healthy Danish infants. Pediatr Res. 2008 Dec;64(6):610-4. doi: 10.1203/PDR.0b013e318186e5c5. | |
| 17460496 | Result | Nielsen S, Nielsen DS, Lauritzen L, Jakobsen M, Michaelsen KF. Impact of diet on the intestinal microbiota in 10-month-old infants. J Pediatr Gastroenterol Nutr. 2007 May;44(5):613-8. doi: 10.1097/MPG.0b013e3180406a11. |
| Label | URL |
|---|---|
| Damsgaard CT, Schack-Nielsen L, Michaelsen KF, Fruekilde MB, Hels O, Lauritzen L. Fish oil affects blood pressure and the plasma lipid profile in healthy danish infants. J Nutr 2006;136:94-9. | View source |
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| ID | Term |
|---|---|
| D009765 | Obesity |
| D024821 | Metabolic Syndrome |
| D002318 | Cardiovascular Diseases |
| D001942 | Breast Feeding |
| ID | Term |
|---|---|
| D050177 | Overweight |
| D044343 | Overnutrition |
| D009748 | Nutrition Disorders |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D008892 | Milk |
| D005395 | Fish Oils |
| D005526 | Food, Formulated |
| ID | Term |
|---|---|
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D003611 | Dairy Products |
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| In vitro cytokine production from stimulated full blood (IL-10, IFN-gamma, TNF-alpha) |
| Plasma IgE, IL-2R, and CRP |
| Iron status (hemoglobin, ferritin and transferrin receptors) |
| Feces samples: Calprotectin, IgA and composition of the intestinal microbiota |
| 17374672 | Result | Damsgaard CT, Lauritzen L, Kjaer TM, Holm PM, Fruekilde MB, Michaelsen KF, Frokiaer H. Fish oil supplementation modulates immune function in healthy infants. J Nutr. 2007 Apr;137(4):1031-6. doi: 10.1093/jn/137.4.1031. |
| 16365065 | Result | Damsgaard CT, Schack-Nielsen L, Michaelsen KF, Fruekilde MB, Hels O, Lauritzen L. Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants. J Nutr. 2006 Jan;136(1):94-9. doi: 10.1093/jn/136.1.94. |
| D001835 |
| Body Weight |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D005247 | Feeding Behavior |
| D001519 | Behavior |
| D005502 |
| Food |
| D019602 | Food and Beverages |
| D009821 | Oils |
| D008055 | Lipids |
| D019648 | Foods, Specialized |