Safety and Efficacy Pilot Study of AzaSite (Azithromycin) in Subjects With Blepharitis

A Single-Center, Open-Label, Randomized Pilot Study of the Safety and Efficacy of AzaSite® Ophthalmic Solution, 1% in Combination With Mechanical Therapy Versus Mechanical Therapy Alone for Two Weeks in Subjects With Posterior Blepharitis

The purpose of this study is to evaluate the safety and efficacy of AzaSite ophthalmic solution, 1% on signs and symptoms of blepharitis.

Inclusion Criteria:

• diagnosis of moderate to severe chronic posterior blepharitis
• if female of childbearing potential, are non-pregnant and non-lactating

Exclusion Criteria:

• had ocular surface surgery (LASIK, refractive, etc.) within the past year
• unwilling to discontinue use of contact lenses during the study
• have glaucoma
• unable or unwilling to withhold the use of lid scrubs during the study
• have a serious systemic disease or uncontrolled medical condition that in the judgment of the investigator could confound study assessments or limit compliance
• currently using any preserved topical ocular medications (with the exception of unpreserved tear substitutes) at the time of entry into the study or during study participation