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| Name | Class |
|---|---|
| Military Medical Academy, Bulgaria | OTHER |
| Dokuz Eylul University | OTHER |
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Low frequency (1Hz) rTMS applied bilaterally and simultaneously over SMA for 6 weeks in addition to the standard treatment regimen for OCD, will lead to significant improvement in patients' symptoms. The clinical improvement detected by YBOCS, CGI and SF-36 QOLS scores will be statistically significant in active treatment group compared to sham (placebo) treatment group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental |
| |
| 2 | Placebo Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| repetitive transcranial magnetic stimulation | Device | 6 weeks of stimulation with RMT frequency 1Hz, intensity 110% of RMT for 20 minutes, 5 minutes of trains with 2 minutes of intra-train intervals to both SMA. Treatment will be given 5 times a week for 4 weeks, 3 times a week during Week 5 and 2 times a week during Week 6. |
| Measure | Description | Time Frame |
|---|---|---|
| Yale-Brown Obsessive Compulsive Scale (YBOCS) | pre, week 1, 2, 4, 6, 8, 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Clinical Global Impression | pre, week 1, 2, 4, 6, 8, 12 | |
| Hamilton Depression Rating Scale-21(HDRS) | pre, week 1, 2, 4, 6, 8, 12 | |
| Pittsburgh Sleep Quality Index (PSQI) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Roumen Milev, MD | Queen's University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Military Medical Academy | Sofia | Bulgaria | ||||
| Providence Care, Mental Health Services |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 27011177 | Derived | Hawken ER, Dilkov D, Kaludiev E, Simek S, Zhang F, Milev R. Transcranial Magnetic Stimulation of the Supplementary Motor Area in the Treatment of Obsessive-Compulsive Disorder: A Multi-Site Study. Int J Mol Sci. 2016 Mar 22;17(3):420. doi: 10.3390/ijms17030420. |
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| ID | Term |
|---|---|
| D009771 | Obsessive-Compulsive Disorder |
| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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| sham (placebo) | Device | Sham treatment will mimic active treatment mentioned above. |
|
|
| pre, week 1, 2, 4, 6, 8, 12 |
| Hamilton Anxiety Rating Scale (HARS) | pre, week 1, 2, 4, 6, 8, 12 |
| SF-36 QOLS version (1) | pre, week 1, 2, 4, 6, 8, 12 |
| Visual Analogue Scale | pre, week 1, 2, 4, 6, 8, 12 |
| Kingston |
| Ontario |
| K7L 4X3 |
| Canada |
| Dokuz Eylul University | Izmir | Turkey (Türkiye) |