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| ID | Type | Description | Link |
|---|---|---|---|
| VA Merit Grant |
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| Name | Class |
|---|---|
| VA Connecticut Healthcare System | FED |
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This Project will explore the hypothesis that individuals with a family history positive for alcohol dependence (without any current Axis I disorder, except nicotine dependence), experience an alteration in the reward "valence" (balance of positive and negative effects) of the GABAA receptor agonist barbiturate (thiopental) compared to family history negative age-matched subjects. Further, variation in genes involved in brain GABA function may influence the risk for alcoholism by altering a component of the discriminative stimulus effects of ethanol.
This project will explore the hypothesis that individuals with a family history positive for alcohol dependence (FHP) (without any current DSM-IV Axis I disorder, except nicotine dependence), experience an alteration in the reward "valence" (balance of positive and negative effects) of the GABA-A receptor agonist barbiturate (thiopental) compared to family history negative (FHN) age-matched subjects. Further, the effect of variations in genes important in regulating brain GABA function may alter a component of the discriminative stimulus effects of ethanol. FHP individuals are defined as individuals with at least one first-degree relative and another first- or second-degree relatives. Preliminary results suggest that FHP individuals showed an attenuated response to thiopental as measured by the descending limb of the BAES during thiopental infusion relative to the FHN group. Further, preliminary results suggest that variation in genes involved in brain GABA function, glutamate decarboxylase-65 (GAD65), may influence the risk for alcoholism by altering a component of the discriminative stimulus effects of ethanol.
We plan to recruit 2 groups of healthy subjects between the ages of 21-30, one with a family history of alcoholism (family history positive=FHP) and a sex-matched control group without a family history of alcoholism (family history negative=FHN), to undergo two test days scheduled 3 days apart, in a randomized double-blind fashion. Test days will involve a 60-minute intravenous infusion of each of 2 conditions: saline or thiopental, in a randomized order under double-blind conditions. Behavioral ratings include the Biphasic Alcohol Effects Scale (BAES) and Visual Analog Scales (VAS). Exploratory measures include event-related potential recordings (ERP) and measures of eye-to-hand coordination. Blood will be collected for Deoxyribonucleic acid (DNA) extraction and genotyping.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Family History Negative for Alcoholism | Active Comparator | Family History Negative for Alcoholism subjects will receive 2 interventions |
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| Family History Positive for Alcoholism | Placebo Comparator | Family History Positive for Alcoholism subjects will receive 2 interventions |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Thiopental | Drug | A 2-day test design involving 2 conditions: saline (Placebo) or Thiopental 1.5mg/kg (loading) with a subsequent infusion rate of 40 mcg/kg/minute (60 minute infusion). |
| Measure | Description | Time Frame |
|---|---|---|
| Visual Analog Scales of Similarity to Alcohol - Baseline | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | Baseline |
| Visual Analog Scales of Similarity to Alcohol - 15 Minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | 15 minutes |
| Visual Analog Scales of Similarity to Alcohol - 45 Minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | 45 minutes |
| Visual Analog Scales of Similarity to Alcohol - 80 Minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | 80 minutes |
| Visual Analog Scales of Similarity to Alcohol - 110 Minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | 110 minutes |
| Visual Analog Scales of Similarity to Alcohol - 170 Minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol |
| Measure | Description | Time Frame |
|---|---|---|
| Number of Drinks Felt Consumed at Baseline | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | Baseline |
| Number of Drinks Felt Consumed - 15 Minutes |
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Inclusion Criteria:
Exclusion Criteria:
For Family History Negative Subjects: NO family history of alcoholism in any first or second-degree relatives. Subjects must reliably report on three first-degree relatives.
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| Name | Affiliation | Role |
|---|---|---|
| Ismene L Petrakis, MD | Yale University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VA Connecticut Healthcare System | West Haven | Connecticut | 06516 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24273687 | Result | Petrakis IL, Kerfoot K, Pittman B, Perrino A, Koretski J, Newcomb J, Limoncelli D, Acampora G, Ralevski E. Subjective Effects of Thiopental in Young Adults with and without a Family History of Alcoholism. J Addict Res Ther. 2012 May 14;Suppl 7(2):6336. doi: 10.4172/2155-6105.S7-002. |
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| ID | Title | Description |
|---|---|---|
| FG000 | Family History Negative for Alcoholism | Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 30 yrs, medically healthy, who have been absence of any evidence of substance abuse (with the exception of nicotine dependence) diagnosis by the non-patient version of the structured clinical interview (SCID). No family history of alcoholism in any first or second-degree relatives. |
| FG001 | Family History Positive for Alcoholism | Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 30 yrs, medically healthy, who have been absence of any evidence of substance abuse (with the exception of nicotine dependence) diagnosis by the non-patient version of the structured clinical interview (SCID). Biological father and another first or second-degree biological relative with a history of alcoholism by Family History Assessment Module (FHAM) developed by The Collaborative Study on the Genetics of Alcoholism (COGA). |
| Title | Milestones | Reasons Not Completed | |||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
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| ID | Title | Description |
|---|---|---|
| BG000 | Family History Negative for Alcoholism | Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 30 yrs, medically healthy, who have been absence of any evidence of substance abuse (with the exception of nicotine dependence) diagnosis by the non-patient version of the structured clinical interview (SCID). No family history of alcoholism in any first or second-degree relatives. |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Categorical | Count of Participants |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Visual Analog Scales of Similarity to Alcohol - Baseline | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | Baseline |
|
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There were no adverse events in this trial, so events are not listed separately for each intervention but are reported by trial arm.
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Family History Negative for Alcoholism | Family History Negative for Alcoholism subjects will receive 2 interventions Thiopental: A 2-day test design involving 2 conditions: saline (Placebo) or Thiopental 1.5mg/kg (loading) with a subsequent infusion rate of 40 mcg/kg/minute (60 minute infusion). |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Ismene L. Petrakis, Professor of Psychiatry | Yale University School of Medicine | 203-932-5711 | 2244 | Ismene.petrakis@yale.edu |
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| ID | Term |
|---|---|
| D000437 | Alcoholism |
| ID | Term |
|---|---|
| D019973 | Alcohol-Related Disorders |
| D019966 | Substance-Related Disorders |
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D013874 | Thiopental |
| ID | Term |
|---|---|
| D013858 | Thiobarbiturates |
| D001463 | Barbiturates |
| D011744 | Pyrimidinones |
| D011743 | Pyrimidines |
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| Placebo | Drug | A 2-day test design involving 2 conditions: saline (Placebo) or Thiopental 1.5mg/kg (loading) with a subsequent infusion rate of 40 mcg/kg/minute (60 minute infusion). |
|
| 170 minutes |
| Visual Analog Scales of Similarity to Alcohol - 230 Minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | 230 minutes |
The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed.
| 15 minutes |
| Number of Drinks Felt Consumed - 45 Minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | 45 minutes |
| Number of Drinks Felt Consumed - 80 Minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | 80 minutes |
| Number of Drinks Felt Consumed - 110 Minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | 110 minutes |
| Number of Drinks Felt Consumed - 170 Minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | 170 minutes |
| Number of Drinks Felt Consumed - 230 Minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | 230 minutes |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - Baseline | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | Baseline |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 15 Minutes | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | 15 minutes |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 45 Minutes | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | 45 minutes |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 80 Minutes | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | 80 minutes |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant- 110 Minutes | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | 110 minutes |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 170 Minutes | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | 170 minutes |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 230 Minutes | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | 230 minutes |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative Baseline | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | Baseline |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 15 Minutes | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | 15 minutes |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 45 Minutes | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | 45 minutes |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 80 Minutes | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | 80 minutes |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 110 Minutes | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | 110 minutes |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 170 Minutes | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | 170 minutes |
| Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 230 Minutes | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | 230 minutes |
| Visual Analog Scales (VAS) - High - Baseline | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | Baseline |
| Visual Analog Scales (VAS) - High - 15 Minutes | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | 15 minutes |
| Visual Analog Scales (VAS) - High - 45 Minutes | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | 45 minutes |
| Visual Analog Scales (VAS) - High - 80 Minutes | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | 80 minutes |
| Visual Analog Scales (VAS) - High - 110 Minutes | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | 110 minutes |
| Visual Analog Scales (VAS) - High - 170 Minutes | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | 170 minutes |
| Visual Analog Scales (VAS) - High - 230 Minutes | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | 230 minutes |
| Visual Analog Scales (VAS) - Buzzed - Baseline | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) | Baseline |
| Visual Analog Scales (VAS) - Buzzed - 15 Minutes | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) | 15 minutes |
| Visual Analog Scales (VAS) - Buzzed - 45 Minutes | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) | 45 minutes |
| Visual Analog Scales (VAS) - Buzzed - 80 Minutes | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) . | 80 minutes |
| Visual Analog Scales (VAS) - Buzzed - 110 Minutes | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) | 110 minutes |
| Visual Analog Scales (VAS) - Buzzed - 170 Minutes | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) | 170 minutes |
| Visual Analog Scales (VAS) - Buzzed - 230 Minutes | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) | 230 minutes |
| Visual Analog Scales (VAS) - Drowsy - Baseline | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) | Baseline |
| Visual Analog Scales (VAS) - Drowsy - 15 Minutes | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) | 15 minutes |
| Visual Analog Scales (VAS) - Drowsy - 45 Minutes | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) . | 45 minutes |
| Visual Analog Scales (VAS) - Drowsy - 80 Minutes | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) | 80 minutes |
| Visual Analog Scales (VAS) - Drowsy - 110 Minutes | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) | 110 minutes |
| Visual Analog Scales (VAS) - Drowsy - 170 Minutes | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) | 170 minutes |
| Visual Analog Scales (VAS) - Drowsy - 230 Minutes | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) | 230 minutes |
| Visual Analog Scales (VAS) - Depressed - Baseline | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | Baseline |
| Visual Analog Scales (VAS) - Depressed - 15 Minutes | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | 15 minutes |
| Visual Analog Scales (VAS) - Depressed - 45 Minutes | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | 45 minutes |
| Visual Analog Scales (VAS) - Depressed - 80 Minutes | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | 80 minutes |
| Visual Analog Scales (VAS) - Depressed - 110 Minutes | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | 110 minutes |
| Visual Analog Scales (VAS) - Depressed - 170 Minutes | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | 170 minutes |
| Visual Analog Scales (VAS) - Depressed - 230 Minutes | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | 230 minutes |
| Visual Analog Scales (VAS) - Anxious - Baseline | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | Baseline |
| Visual Analog Scales (VAS) - Anxious - 15 Minutes | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | 15 minutes |
| Visual Analog Scales (VAS) - Anxious - 45 Minutes | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | 45 minutes |
| Visual Analog Scales (VAS) - Anxious - 80 Minutes | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | 80 minutes |
| Visual Analog Scales (VAS) - Anxious - 110 Minutes | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | 110 minutes |
| Visual Analog Scales (VAS) - Anxious - 170 Minutes | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | 170 minutes |
| Visual Analog Scales (VAS) - Anxious - 230 Minutes | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | 230 minutes |
| Clinician Administered Dissociative Symptoms Scale - Patient Rated - Baseline | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative) | Baseline |
| Clinician Administered Dissociative Symptoms Scale - Patient Rated - 15 Minutes | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative) | 15 minutes |
| Clinician Administered Dissociative Symptoms Scale - Patient Rated - 80 Minutes | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative) | 80 minutes |
| Clinician Administered Dissociative Symptoms Scale - Patient Rated - 110 Minutes | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative) | 110 minutes |
| Clinician Administered Dissociative Symptoms Scale - Clinician Rated - Baseline | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative) | Baseline |
| Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 15 Minutes | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative) | 15 minutes |
| Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 80 Minutes | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative) | 80 minutes |
| Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 110 Minutes | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative) | 110 minutes |
| Pegboard Task - Baseline (Dominant Hand) | The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds | Baseline |
| Pegboard Task - 15 Minutes (Dominant Hand) | The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds | 15 minutes |
| Pegboard Task - Baseline (Non-Dominant Hand) | The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds. | Baseline |
| Pegboard Task - 15 Minutes (Non-Dominant Hand) | The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds. | 15 minutes |
| Hopkins Verbal Learning Task (HVLT) - Total Recall | Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function based on word recall. (0 = no words recalled - 36 = all words recalled) | 15 minutes |
| Hopkins Verbal Learning Task (HVLT) - Delayed Recall | Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function with word recall at 30 minutes) (0 no words recalled - 12 all words recalled) | 45 minutes |
| Verbal Fluency | Verbal Fluency Task: requires subjects to generate as many words as possible beginning with a single letter (e.g., "H") during a one-minute interval. (total words in one-minute interval) | 15 minutes |
| didn't like the medication |
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| Physician Decision |
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| BG001 | Family History Positive for Alcoholism | Male or female (post-menopausal, surgically sterile, or negative pregnancy test at screening and agreement to utilize an established birth control during the testing period) between the age of 21 and 30 yrs, medically healthy, who have been absence of any evidence of substance abuse (with the exception of nicotine dependence) diagnosis by the non-patient version of the structured clinical interview (SCID). Biological father and another first or second-degree biological relative with a history of alcoholism by Family History Assessment Module (FHAM) developed by COGA. |
| BG002 | Total | Total of all reporting groups |
| Participants |
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| Age, Continuous | Mean | Standard Deviation | years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Primary | Visual Analog Scales of Similarity to Alcohol - 15 Minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 15 minutes |
|
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| Primary | Visual Analog Scales of Similarity to Alcohol - 45 Minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 45 minutes |
|
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| Primary | Visual Analog Scales of Similarity to Alcohol - 80 Minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 80 minutes |
|
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| Primary | Visual Analog Scales of Similarity to Alcohol - 110 Minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 110 minutes |
|
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| Primary | Visual Analog Scales of Similarity to Alcohol - 170 Minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 170 minutes |
|
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| Primary | Visual Analog Scales of Similarity to Alcohol - 230 Minutes | Visual Analog Scale of Similarity to Alcohol data using the Likert scale (0 Not at all similar to alcohol - 7 Extremely similar to alcohol) evaluating the similarity of drug effects to alcohol | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 230 minutes |
|
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| Secondary | Number of Drinks Felt Consumed at Baseline | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | number of drinks felt consumed | Baseline |
|
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| Secondary | Number of Drinks Felt Consumed - 15 Minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | number of drinks felt consumed | 15 minutes |
|
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| Secondary | Number of Drinks Felt Consumed - 45 Minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | number of drinks felt consumed | 45 minutes |
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| Secondary | Number of Drinks Felt Consumed - 80 Minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | number of drinks felt consumed | 80 minutes |
|
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| Secondary | Number of Drinks Felt Consumed - 110 Minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | number of drinks felt consumed | 110 minutes |
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| Secondary | Number of Drinks Felt Consumed - 170 Minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | number of drinks felt consumed | 170 minutes |
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| Secondary | Number of Drinks Felt Consumed - 230 Minutes | The Number of Drinks Scale asks Subjects to report on the number of alcoholic drinks they felt they had consumed. | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | number of drinks felt consumed | 230 minutes |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - Baseline | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | Baseline |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 15 Minutes | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 15 minutes |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 45 Minutes | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 45 minutes |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 80 Minutes | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 80 minutes |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant- 110 Minutes | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 110 minutes |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 170 Minutes | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 170 minutes |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Stimulant - 230 Minutes | Self-report rating scale used to measure stimulant effects (0 not at all stimulated - 70 extremely stimulated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 230 minutes |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative Baseline | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | Baseline |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 15 Minutes | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | All available data was utilized in the analysis using mixed models | Posted | Mean | Standard Deviation | units on a scale | 15 minutes |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 45 Minutes | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 45 minutes |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 80 Minutes | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 80 minutes |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 110 Minutes | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 110 minutes |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 170 Minutes | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 170 minutes |
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| Secondary | Biphasic Alcohol Effects Scale (BAES) - Subscale Sedative - 230 Minutes | Self-report rating scale used to measure sedative effects (0 not at all sedated - 70 extremely sedated) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 230 minutes |
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| Secondary | Visual Analog Scales (VAS) - High - Baseline | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | Baseline |
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| Secondary | Visual Analog Scales (VAS) - High - 15 Minutes | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 15 minutes |
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| Secondary | Visual Analog Scales (VAS) - High - 45 Minutes | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | All available data was utilized in the analysis using mixed models | Posted | Mean | Standard Deviation | units on a scale | 45 minutes |
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| Secondary | Visual Analog Scales (VAS) - High - 80 Minutes | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | All available data was utilized in the analysis using mixed models | Posted | Mean | Standard Deviation | units on a scale | 80 minutes |
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| Secondary | Visual Analog Scales (VAS) - High - 110 Minutes | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | All available data was utilized in the analysis using mixed models | Posted | Mean | Standard Deviation | units on a scale | 110 minutes |
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| Secondary | Visual Analog Scales (VAS) - High - 170 Minutes | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | All available data was utilized in the analysis using mixed models | Posted | Mean | Standard Deviation | units on a scale | 170 minutes |
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| Secondary | Visual Analog Scales (VAS) - High - 230 Minutes | visual analog scale (VAS): self-report scale used to measure high (0 not at all High - 7 extremely High) | All available data was utilized in the analysis using mixed models | Posted | Mean | Standard Deviation | units on a scale | 230 minutes |
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| Secondary | Visual Analog Scales (VAS) - Buzzed - Baseline | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) | All available data was utilized in the analysis using mixed models | Posted | Mean | Standard Deviation | units on a scale | Baseline |
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| Secondary | Visual Analog Scales (VAS) - Buzzed - 15 Minutes | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) | All available data was utilized in the analysis using mixed models | Posted | Mean | Standard Deviation | units on a scale | 15 minutes |
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| Secondary | Visual Analog Scales (VAS) - Buzzed - 45 Minutes | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) | All available data was utilized in the analysis using mixed models | Posted | Mean | Standard Deviation | units on a scale | 45 minutes |
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| Secondary | Visual Analog Scales (VAS) - Buzzed - 80 Minutes | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) . | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 80 minutes |
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| Secondary | Visual Analog Scales (VAS) - Buzzed - 110 Minutes | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 110 minutes |
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| Secondary | Visual Analog Scales (VAS) - Buzzed - 170 Minutes | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 170 minutes |
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| Secondary | Visual Analog Scales (VAS) - Buzzed - 230 Minutes | visual analog scale (VAS): self-report scale used to measure buzzed (0 not at all buzzed - 7 extremely buzzed) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 230 minutes |
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| Secondary | Visual Analog Scales (VAS) - Drowsy - Baseline | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | Baseline |
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| Secondary | Visual Analog Scales (VAS) - Drowsy - 15 Minutes | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 15 minutes |
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| Secondary | Visual Analog Scales (VAS) - Drowsy - 45 Minutes | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) . | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 45 minutes |
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| Secondary | Visual Analog Scales (VAS) - Drowsy - 80 Minutes | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 80 minutes |
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| Secondary | Visual Analog Scales (VAS) - Drowsy - 110 Minutes | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 110 minutes |
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| Secondary | Visual Analog Scales (VAS) - Drowsy - 170 Minutes | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 170 minutes |
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| Secondary | Visual Analog Scales (VAS) - Drowsy - 230 Minutes | visual analog scale (VAS): self-report scale used to measure drowsy (0 not at all drowsy - 7 extremely drowsy) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 230 minutes |
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| Secondary | Visual Analog Scales (VAS) - Depressed - Baseline | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | Baseline |
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| Secondary | Visual Analog Scales (VAS) - Depressed - 15 Minutes | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 15 minutes |
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| Secondary | Visual Analog Scales (VAS) - Depressed - 45 Minutes | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 45 minutes |
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| Secondary | Visual Analog Scales (VAS) - Depressed - 80 Minutes | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 80 minutes |
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| Secondary | Visual Analog Scales (VAS) - Depressed - 110 Minutes | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 110 minutes |
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| Secondary | Visual Analog Scales (VAS) - Depressed - 170 Minutes | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 170 minutes |
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| Secondary | Visual Analog Scales (VAS) - Depressed - 230 Minutes | visual analog scale (VAS): self-report scale used to measure depressed (0 not at all depressed - 7 extremely depressed) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 230 minutes |
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| Secondary | Visual Analog Scales (VAS) - Anxious - Baseline | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | Baseline |
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| Secondary | Visual Analog Scales (VAS) - Anxious - 15 Minutes | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 15 minutes |
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| Secondary | Visual Analog Scales (VAS) - Anxious - 45 Minutes | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 45 minutes |
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| Secondary | Visual Analog Scales (VAS) - Anxious - 80 Minutes | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 80 minutes |
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| Secondary | Visual Analog Scales (VAS) - Anxious - 110 Minutes | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 110 minutes |
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| Secondary | Visual Analog Scales (VAS) - Anxious - 170 Minutes | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 170 minutes |
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| Secondary | Visual Analog Scales (VAS) - Anxious - 230 Minutes | visual analog scale (VAS): self-report scale used to measure anxiety (0 not at all anxious - 7 extremely anxious) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 230 minutes |
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| Secondary | Clinician Administered Dissociative Symptoms Scale - Patient Rated - Baseline | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | Baseline |
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| Secondary | Clinician Administered Dissociative Symptoms Scale - Patient Rated - 15 Minutes | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 15 minutes |
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| Secondary | Clinician Administered Dissociative Symptoms Scale - Patient Rated - 80 Minutes | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 80 minutes |
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| Secondary | Clinician Administered Dissociative Symptoms Scale - Patient Rated - 110 Minutes | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 84 extreme dissociative) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 110 minutes |
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| Secondary | Clinician Administered Dissociative Symptoms Scale - Clinician Rated - Baseline | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | Baseline |
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| Secondary | Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 15 Minutes | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 15 minutes |
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| Secondary | Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 80 Minutes | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 80 minutes |
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| Secondary | Clinician Administered Dissociative Symptoms Scale - Clinician Rated - 110 Minutes | Clinician Administered Dissociative Symptoms Scale (CADSS) is a patient and Clinician rated measurement of dissociative states induced by thiopental (0 not at all dissociative - 20 extreme dissociative) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | units on a scale | 110 minutes |
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| Secondary | Pegboard Task - Baseline (Dominant Hand) | The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | seconds | Baseline |
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| Secondary | Pegboard Task - 15 Minutes (Dominant Hand) | The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | seconds | 15 minutes |
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| Secondary | Pegboard Task - Baseline (Non-Dominant Hand) | The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds. | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | seconds | Baseline |
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| Secondary | Pegboard Task - 15 Minutes (Non-Dominant Hand) | The pegboard task is a measure of coordination that measures reaction time; how long a subject takes to insert pegs into a pegboard puzzle, first using their dominant hand then using their non-dominant hand. A quicker time indicates greater coordination. Scores are timed in seconds. | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | seconds | 15 minutes |
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| Secondary | Hopkins Verbal Learning Task (HVLT) - Total Recall | Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function based on word recall. (0 = no words recalled - 36 = all words recalled) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | words recalled | 15 minutes |
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| Secondary | Hopkins Verbal Learning Task (HVLT) - Delayed Recall | Hopkins Verbal Learning Task (HVLT) - measures verbal memory and hippocampus function with word recall at 30 minutes) (0 no words recalled - 12 all words recalled) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | words recalled | 45 minutes |
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| Secondary | Verbal Fluency | Verbal Fluency Task: requires subjects to generate as many words as possible beginning with a single letter (e.g., "H") during a one-minute interval. (total words in one-minute interval) | All available data was utilized in the analysis using mixed models. | Posted | Mean | Standard Deviation | number of words | 15 minutes |
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| EG001 | Family History Positive for Alcoholism | Family History Positive for Alcoholism subjects will receive 2 interventions Placebo: A 2-day test design involving 2 conditions: saline (Placebo) or Thiopental 1.5mg/kg (loading) with a subsequent infusion rate of 40 mcg/kg/minute (60 minute infusion). | 0 | 24 | 0 | 24 |
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