Dose Response Effects of Inhaled Fluticasone on Airway Effects of Hypertonic-saline in Asthma

A Randomized Double Blind Study of the Dose Response Effects of Fluticasone Propionate on Hypertonic-saline Induced Bronchoconstriction in Asthmatic Subjects

This study investigates the effect of a inhaled corticosteroid (fluticasone or "Flovent") on airway narrowing induced by hypertonic saline (salty water). The study hypothesis is that fluticasone will be more effective in preventing saline-induced airway narrowing than methacholine-induced narrowing.

Inclusion Criteria:

• Clinical diagnosis of asthma

Exclusion Criteria:

• Habitual cigarette smoking