Effect of Fluticasone Furoate on Methacholine Challenge

The Effect of Once-daily Fluticasone Furoate on Methacholine-induced Bronchoconstriction in Mild Asthmatics

The study will determine the effect of inhaled fluticasone furoate on airway responsiveness to methacholine in mild asthmatics.

Inclusion Criteria:

• forced expiratory volume in one second (FEV1) greater than or equal to 65% predicted
• methacholine PD20 less than or equal to 400mcg
• no allergen exposure (if atopic) or respiratory infection for at least 4 weeks prior to study start

Exclusion Criteria:

• regular use of inhaled corticosteroid within 4 weeks of study start
• poorly controlled asthma
• current smoker or ex smoker with greater than 10 pack year history
• pregnancy or breast-feeding
• health concern/condition that would preclude participation for safety reasons