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| ID | Type | Description | Link |
|---|---|---|---|
| NINDS 5 U01NS050095-02 | |||
| U01NS050095 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Neurological Disorders and Stroke (NINDS) | NIH |
| H. Lundbeck A/S | INDUSTRY |
| Parkinson's Disease Foundation | OTHER |
| United States Department of Defense |
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The purpose of this study is to longitudinally follow consenting clinical trial participants who participated in PRECEPT (A Randomized, Double Blind, Placebo Controlled, Dose Finding Study to Assess the Efficacy and Safety of CEP 1347 in Patients With Early Parkinson's Disease). The study will assess the clinical and imaging outcomes relevant to the natural history of Parkinson's disease (PD), as well as determine early biomarkers of the disease.
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| Measure | Description | Time Frame |
|---|---|---|
| Unified Parkinson Disease Rating Scale (UPDRS) and β-CIT SPECT imaging of the dopamine transporter. | Annual, ongoing assessments |
| Measure | Description | Time Frame |
|---|---|---|
| University of Pennsylvania Smell Identification Test (UPSIT) | Annual, ongoing assessments |
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Inclusion Criteria:
Exclusion Criteria:
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Parkinson disease patients who participated in the PRECEPT clinical trial.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Barrow Neurological Institute | Phoenix | Arizona | United States | |||
| Sun Health Research Institute |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17881719 | Background | Parkinson Study Group PRECEPT Investigators. Mixed lineage kinase inhibitor CEP-1347 fails to delay disability in early Parkinson disease. Neurology. 2007 Oct 9;69(15):1480-90. doi: 10.1212/01.wnl.0000277648.63931.c0. Epub 2007 Sep 19. | |
| 28958801 | Derived | Latourelle JC, Beste MT, Hadzi TC, Miller RE, Oppenheim JN, Valko MP, Wuest DM, Church BW, Khalil IG, Hayete B, Venuto CS. Large-scale identification of clinical and genetic predictors of motor progression in patients with newly diagnosed Parkinson's disease: a longitudinal cohort study and validation. Lancet Neurol. 2017 Nov;16(11):908-916. doi: 10.1016/S1474-4422(17)30328-9. Epub 2017 Sep 25. |
| Label | URL |
|---|---|
| The Parkinson Study Group (PSG) is a non-profit, cooperative group of Parkinson's disease experts from medical centers in theUnited States and Canada who are dedicated to improving treatment for persons affected by Parkinson's disease. | View source |
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| FED |
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Whole blood
| Sun City |
| Arizona |
| United States |
| University of Arkansas for Medical Sciences | Little Rock | Arkansas | United States |
| The Parkinson's & Movement Disorder Institute | Fountain Valley | California | United States |
| University of California Irvine | Irvine | California | United States |
| University of San Diego | La Jolla | California | United States |
| University of Southern California | Los Angeles | California | United States |
| Pacific Neuroscience Medical Group | Oxnard | California | United States |
| University of California Davis | Sacramento | California | United States |
| The Parkinson's Institute | Sunnyvale | California | United States |
| University of Colorado Health Sciences Center | Aurora | Colorado | United States |
| Colorado Neurological Institute | Littleton | Colorado | United States |
| Institute for Neurogenerative Disorders | New Haven | Connecticut | United States |
| Mayo Clinic Jacksonville | Jacksonville | Florida | United States |
| University of South Florida | Tampa | Florida | United States |
| Cleveland Clinic Florida-Weston | Weston | Florida | United States |
| Medical College of Georgia | Augusta | Georgia | United States |
| Northwestern University | Chicago | Illinois | United States |
| Rush University Medical Center | Chicago | Illinois | United States |
| University of Chicago | Chicago | Illinois | United States |
| University of Iowa | Iowa City | Iowa | United States |
| University of Kansas Medical Center | Kansas City | Kansas | United States |
| LSU Health Science Center Shreveport | Shreveport | Louisiana | United States |
| Johns Hopkins University | Baltimore | Maryland | United States |
| University of Maryland School of Medicine | Baltimore | Maryland | United States |
| Beth Israel Deaconess Medical Center | Boston | Massachusetts | United States |
| Boston University | Boston | Massachusetts | United States |
| Brigham & Women's Hospital | Boston | Massachusetts | United States |
| Massachusetts General Hospital | Boston | Massachusetts | United States |
| University of Minnesota | Minneapolis | Minnesota | United States |
| Creighton University | Omaha | Nebraska | United States |
| UMDNJ Robert Wood Johnson Medical School | New Brunswick | New Jersey | United States |
| Albany Medical College | Albany | New York | United States |
| North Shore-LIJ Health System | Manhasset | New York | United States |
| Beth Israel Medical Center | New York | New York | United States |
| Columbia University | New York | New York | United States |
| University of Rochester | Rochester | New York | United States |
| Duke University Medical Center | Durham | North Carolina | United States |
| University of Cincinnati/Cincinnati Children's Hospital | Cincinnati | Ohio | United States |
| Oregon Health & Science University | Portland | Ohio | United States |
| Medical University of Ohio | Toledo | Ohio | United States |
| Milton S. Hershey Medical Center | Hershey | Pennsylvania | United States |
| University of Pennsylvania | Philadelphia | Pennsylvania | United States |
| NeuroHealth Parkinson's Disease Movement Disorders Center | Warwick | Rhode Island | United States |
| University of Tennessee-Memphis | Memphis | Tennessee | United States |
| Baylor College of Medicine | Houston | Texas | United States |
| University of Virginia | Charlottesville | Virginia | United States |
| University of Calgary | Calgary | Alberta | Canada |
| University of Alberta | Edmonton | Alberta | Canada |
| London Health Sciences Centre | London | Ontario | Canada |
| Ottawa Hospital Civic Site | Ottawa | Ontario | Canada |
| Toronto Western Hospital, University Health Network | Toronto | Ontario | Canada |
| University of Sherbrooke | Fleurimont | Quebec | Canada |
| Hotel-Dieu Hospital-CHUM | Montreal | Quebec | Canada |
| Saskatoon Disrict Health Board Royal University Hospital | Saskatoon | Saskatchewan | Canada |
| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |
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