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| ID | Type | Description | Link |
|---|---|---|---|
| RSRB #09283 |
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Funding for the CALM-PD Cohort Study was terminated by sponsor.
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| Name | Class |
|---|---|
| Pharmacia Corp. (Peapack, NJ) | UNKNOWN |
| Boehringer Ingelheim | INDUSTRY |
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To determine the long-term consequences (8 years) of initiating patients with Parkinson's disease on either pramipexole or levodopa. We hypothesize that patients initiating therapy with pramipexole compared with levodopa will demonstrate less self-reported disability as measured by the Modified Schwab and England (S/E) scale 8 years after randomization.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| no treatment | Available 301 subjects enrolled in CALM-PD Available 82 subjects enrolled in CALM-PD imaging substudy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| No intervention. | Other |
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| Measure | Description | Time Frame |
|---|---|---|
| We hypothesize that patients initiating therapy with pramipexole compared with levodopa will demonstrate less self-reported disability as measured by the Modified Schwab and England. | 8 years from date randomized in CALM study |
| Measure | Description | Time Frame |
|---|---|---|
| Our secondary specific aim is to develop and estimate a structural model that will allow us to uncover the causal pathways through which treatments effect outcomes. | 8 years from randomization of CALM-PD study |
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Inclusion Criteria:
Exclusion Criteria:
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Available 301 subjects enrolled in CALM-PD
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Rochester | Rochester | New York | 14620 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19433655 | Derived | Parkinson Study Group CALM Cohort Investigators. Long-term effect of initiating pramipexole vs levodopa in early Parkinson disease. Arch Neurol. 2009 May;66(5):563-70. doi: 10.1001/archneur.66.1.nct90001. |
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| ID | Term |
|---|---|
| D010300 | Parkinson Disease |
| ID | Term |
|---|---|
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| D009422 | Nervous System Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D019636 | Neurodegenerative Diseases |