Gastric Emptying Study After Administration of a High Caloric Sip Feed

Characterisation of Gastric Emptying of a High Caloric Sip Feed Using the Paracetamol Absorption Method: Intraindividual Comparison of Paracetamol Pharmacokinetics After Oral co-Administration With Sip-Feed and After Intravenous Administration in Healthy Volunteers of Both Genders in an Open, Single Centre Study

Measurement of gastric emptying time of an oral nutritional supplement (ProvideXtra DRINK) by using the paracetamol absorption method in healthy volunteers.

Inclusion Criteria:

• caucasian origin
• BMI: 22kg/m2 - 27kg/m2;

Exclusion Criteria:

• existing diseases and/or pathological findings, which might interfere with the safety, tolerability, absorption and/or pharmacokinetics of paracetamol (e.g. gastrointestinal or liver disease),
• known allergic reactions to investigational products,
• diseases and/or pathological findings, which could affect absorption, metabolism and/or gastric emptying (e.g. dyspepsia and gastroesophageal reflux),
• regular medication which can influence hepatic biotransformation and/or absorption,
• alcohol dependence, blood donation;