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| ID | Type | Description | Link |
|---|---|---|---|
| EUK-B2 |
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| Name | Class |
|---|---|
| German Federal Ministry of Education and Research | OTHER_GOV |
The purpose of this study is to determine how psychotherapy and pharmacotherapy respectively change brain activity in patients suffering from chronic depression.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AD | Active Comparator | Antidepressant Duloxetine |
|
| PT | Active Comparator | Psychotherapy (CBASP) - Cognitive Behavioural Analysis System of Psychotherapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Duloxetine | Drug | Duloxetine 30mg up to 120mg per day. |
| |
| Cognitive Behavioural Analysis System of Psychotherapy |
| Measure | Description | Time Frame |
|---|---|---|
| Neuroimaging Data (fMRI) | Before and After Therapy |
| Measure | Description | Time Frame |
|---|---|---|
| HAMD | Weekly | |
| Salivary Cortisol | Before and After Therapy |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Isabella Heuser, Prof. Dr. med. Dipl. Psych. | Dept. of Psychiatry, Campus Benjamin Franklin, Charité Berlin, Germany | Study Chair |
| Michael Colla, Dr. med. | Department of Psychiatry, Campus Benjamin Franklin, Charité Berlin, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité Universitätsmedizin | Berlin | State of Berlin | 14050 | Germany |
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| ID | Term |
|---|---|
| D003863 | Depression |
| ID | Term |
|---|---|
| D001526 | Behavioral Symptoms |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D000068736 | Duloxetine Hydrochloride |
| ID | Term |
|---|---|
| D013876 | Thiophenes |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D006573 | Heterocyclic Compounds, 1-Ring |
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| Behavioral |
Cognitive Behavioural Analysis System of Psychotherapy (CBASP): 20 sessions of psychotherapy, beginning with twice weekly, then weekly sessions. |
|
| D006571 |
| Heterocyclic Compounds |