Getting Biased Treatment Study: How Psychotherapy and Antidepressants Change Brain Activity in Chronic Depression

Impact of Therapeutical Strategies on Emotional Processing in Depression: Neurofunctional and Clinical Issues in the Context of Affective Bias

The purpose of this study is to determine how psychotherapy and pharmacotherapy respectively change brain activity in patients suffering from chronic depression.

Inclusion Criteria:

• Chronic Depression (Double Depression, Chronic MDE, MDE with incomplete remission)
• HAMD-24>20

Exclusion Criteria:

• Concurrent Psychotherapy or Psychopharmacotherapy
• Previous Non-Response to Duloxetine
• Non-Response to three Antidepressants of two different groups given at adequate doses or Non-Response to two empirically tested forms of Psychotherapy in the current Depressive Episode
• Serious Psychiatric comorbidity
• Serious Neurologic comorbidity
• Contraindications to Duloxetine
• Contraindications to fMRI