Evaluation of Depression Symptoms and Brain Activity Associated With Response to Treatment of Depression

Factors of Treatment Response in Major Depressive Disorder

This study will use measurements of depression symptoms and brain activity to determine what factors may influence an individual's response to treatment for depression.

We are using depression symptom measurements and measurements of brain electrical activity (EEG) to determine what factors may influence whether a patient is likely to show a response to antidepressant medication, placebo, or only clinical visits (without the use of pills) during a treatment trial for depression.

Inclusion Criteria:

• Clinical diagnosis of unipolar major depression

Exclusion Criteria:

• Substance abuse
• Psychotic disorder
• History of severe head trauma