ASA- and Clopidogrel-Responsiveness in Patients With Peripheral Arterial Occlusive Disease and Interventional Procedures

Investigation of Laboratory Resistance to Aspirin and Clopidogrel and Its Clinical Relevance in Patients With Peripheral Arterial Occlusive Disease Requiring Interventional Procedures

The purpose of the study is to determine the response to aspirin (ASA) and Clopidogrel in patients with peripheral arterial occlusive disease (PAOD) requiring interventional procedures and to investigate if patients with "resistance" to ASA or Clopidogrel have an unfavourable outcome during long-term follow-up

Inclusion Criteria:

• PAOD patients
• Age 18-85 years
• Need for a catheter interventional procedure
• Antithrombotic therapy with aspirin or clopidogrel

Exclusion Criteria:

• Comedication additionally compromising platelet function
• Known bleeding disorder
• Life expectancy < 6 months