Resistance on Antithrombotic Drugs in Ischemic Heart Disease

Assessment of Aspirin and Clopidogrel Resistance in Ischemic Heart Disease Using Multiplate Function Analyser and it's Correlation With Major Adverse Cardiac Events

The purpose of this study is to determine whether aspirin and clopidogrel resistance measured with Multiplate function analyser has a good correlation with incidence of major adverse cardiac events in patients with coronary artery disease (CAD).

Our plan is to enroll 180 patients with diagnosed CAD who electively undergo percutaneous coronary intervention (PCI). Blood samples will be taken just before the procedure and one day after the procedure and analysed on Multiplate function analyser. Assessing aspirin and clopidogrel resistance incidence using Multiplate platelet function analyzer we will also try to find resistance correlation with the incidence of major adverse cardiac events in a one year follow up.

Inclusion Criteria:

• Elective PCI
• > 7 days on aspirin 100mg therapy before the intervention
• > 7 days on clopidogrel 75mg therapy before the intervention

Exclusion Criteria:

• Loading dose of clopidogrel
• < 7 days on aspirin therapy before the intervention
• Myocardial infarction less than 30 days before the intervention
• Cerebrovascular incident less that three months before the intervention
• Haemorrhagic diathesis
• Trc < 100
• Htc < 30%
• Creatinine > 140