Intensive Combo Chemo With Autologous BM Rescue for Metastatic Breast Cancer

Intensive Combination Chemotherapy With Autologous Bone Marrow Rescue for Metastatic Breast Cancer After Intitial Cytoreduction With Standard Agents: A Phase II Study

To determine the therapeutic efficacy of high-dose cyclophosphamide and BCNU with autologous bone marrow transplantation after initial tumor cytoreduction for patients with receptor-negative metastatic breast carcinoma and to determine the optimal timing of CyBCNU-ABMT after initial development of metastatic breast carcinoma

Inclusion Criteria:

• breast carcinoma at first clinical evidence of metastatic disease
• must have measurable disease by physical exam, x-ray, or scan
• Age < or equal to 55
• performance status 0-2

Exclusion Criteria:

• can't have had more than one prior chemotherapy regimen
• can't have had concurrent hormonal therapy
• no brain metastases
• no previous pelvic radiation
• no history of another malignancy