High Dose Chemo With Autologous BMT for Treatment of Metastatic Breast Cancer

High Dose Chemotherapy With Autologous Bone Marrow Transplantation in the Treatment of Metastatic Breast Cancer

To evaluate the response rate and the response duration of high dose chemotherapy with autologous bone marrow transplantation as intensification following induction chemotherapy in metastatic breast cancer and to evaluate prospectively the subdivision of patients with metastatic breast cancer according to prognostic groups.

There are 2 phases to this study: 1) Induction- which consists of the administration of chemotherapeutic drugs- at the end of this phase if the cancer has responded, bone marrow will be collected and frozen untol ready for re-infusion; 2) 2nd phase- involves high-doses of chemotherapy followed by infusion of bone marrow cells

Inclusion Criteria:

• Histologically confirmed diagnosis of breast cancer
• Age 18-70
• Breast cancer at first clinical evidence of metastatic disease
• Must have objectively measurable or evaluable disease or be in complete remission

Exclusion Criteria:

• Previous diagnosis of another invasive carcinaom within 10 years (except skin cancer)
• CNS involvement