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The purpose of this study is to evaluate the effects of oral L-Arginine in pregnant women with chronic hypertension.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | Oral L-Arginine 2 g twice a day for 14 weeks |
|
| 2 | Placebo Comparator | Placebo 2 g, twice a day for 14 weeks |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| L-Arginine | Drug | Oral L-Arginine 2g, twice a day for 14 weeks |
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| to evaluate blood pressure changes in pregnant women with chronic hypertension during oral arginine or placebo treatment in second trimester of gestation. | 14 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| To evaluate if is necessary add a conventional therapy for hypertension, to evaluate the maternal and fetal outcomes and possible complications, to evaluate the safety of L-Arginine. | 14 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Fabio Facchinetti, MD | University of Modena and Reggio Emilia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Modena and Reggio Emilia | Modena | Emilia-Romagna | 41100 | Italy |
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| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D006973 | Hypertension |
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| ID | Term |
|---|---|
| D001120 | Arginine |
| ID | Term |
|---|---|
| D024361 | Amino Acids, Basic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |
| D000599 | Amino Acids, Diamino |
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| Drug |
Placebo 2 g twice a day for 14 weeks |
|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D000601 | Amino Acids, Essential |