Efficacy and Safety of L Arginine to Prevent Preeclampsia

Efficacy and Safety of L Arginine to Prevent Preeclampsia in High Risk Pregnancies

Randomized double-blind controled clinical trial to assess the efficacy and safety of L-arginine to prevent preeclampsia.

applied to pregnant women with risk factors for preeclampsia. the main result was the development of preeclampsia as well as side effects to taking l arginine besides perinatal outcomes

Two groups were formed. one received L arginine 3 grams orally at day from the 20th week of pregnancy. the other group received placebo.

Each three weeks were evaluated in search of high blood pressure and proteinuria.

The follow-up was until the end of pregnancy and two weeks after this

Inclusion Criteria:

• one or more risk factors for developing preeclampsia (nulliparous, previous history of preeclampsia, chronic hypertension, BMI ≥30)

Exclusion Criteria:

• pregnant women carriers of chronic renal failure
• pre gestational diabetes
• multiple pregnancy and were removed for some reason they received medication that would interfere with the interpretation of results (aspirin)