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| ID | Type | Description | Link |
|---|---|---|---|
| 255104 | Other Identifier | Kuopio University Hospital |
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Endoscopic dacryocystorhinostomy (EN-DCR) is an effective procedure when treating saccal and postsaccal obstructions of the nasolacrimal pathway. The benefit of silicone tubing after DCR is still controversial. We conducted a prospective, randomized study in order to evaluate 1) the necessity of bicanalicular silicone tubes after primary EN-DCR, 2) efficacy of the perioperative Mitomycin C for the prevention of adheesion and re-stenosis of rhinostomy site in revision EN-DCR, 3) the subjective symptoms and QoL changes before and after DCR-operation.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| with tubes or mitomycin | Active Comparator | After DCR bicanalicular tubes were inserted After re-DCR mitomycin in cottonpads were placed into rhinostoma for 5 minutes |
|
| without tubes or mitomycin | Active Comparator | After DCR no tubes were inserted After re-DCR no mitomycin was used |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| DCR with no tubes or mitomycin | Procedure | The patients were randomized into the two study groups, either with or without the insertion of a bicanalicular silicone tube after primary DCR. In revision group patients were randomized into the two groups,ether with or without application of mitomycin "C" after DCR |
| Measure | Description | Time Frame |
|---|---|---|
| The success rate after primary DCR with and without silicone tubes. The success rate after revisio DCR with and without Mitomycin C. | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| The EN-DCR operation influence on the patients subjective symptoms and QoL before and after operation. | 5 years |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Juha Seppä, MD,PhD | Kuopio University Hospital, Otorhinolaryngology | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kuopio University Hospital | Kuopio | Northern Savonia | 70210 | Finland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24851037 | Background | Penttila E, Hyttinen JM, Hytti M, Kauppinen A, Smirnov G, Tuomilehto H, Seppa J, Nuutinen J, Kaarniranta K. Upregulation of inflammatory genes in the nasal mucosa of patients undergoing endonasal dacryocystorhinostomy. Clin Ophthalmol. 2014 Apr 25;8:799-805. doi: 10.2147/OPTH.S50195. eCollection 2014. |
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| ID | Term |
|---|---|
| D007767 | Lacrimal Duct Obstruction |
| ID | Term |
|---|---|
| D007766 | Lacrimal Apparatus Diseases |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D016685 | Mitomycin |
| ID | Term |
|---|---|
| D008937 | Mitomycins |
| D045563 | Indolequinones |
| D011809 | Quinones |
| D009930 | Organic Chemicals |
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DCR with/ without tubes Revision DCR with/ without mitomycin
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|
|
| D001389 |
| Azirines |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D007211 | Indoles |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |