Continuous Versus Repetitive Sevoflurane Administration for Preconditioning

A Comparison Between Continuous and Repetitive Sevoflurane Administration for Preconditioning During Coronary Artery Bypass Surgery

Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective in terms of attenuating myocardial cell damage compared to a repetitive administration with a double wash in/wash out schedule. A control group will receive propofol as their primary anesthetic.

Inclusion Criteria:

• Patients schedulded to undergo CABG surgery
• Age 18 to 80 years
• Ejection fraction > 40%

Exclusion Criteria:

• Emergency cases
• Diabetes
• Not able to give informed consent
• Ejection fraction < 40%