The purpose of this study is to measure the relative "barrier" function of the top layer of the cornea (called the epithelium), or the degree to which the cornea can prevent the penetration of the colored dye sodium fluorescein into the eye. This is a clinical investigation of the effect on corneal barrier function following wear of two contact lens materials and two contact lens care systems, approved for marketing in the US by the Food and Drug Administration. These contact lenses will be worn for two hours, following soak in one of two marketed contact lens disinfecting solutions. Approximately 25 young, adapted contact lens wearers will participate.

Inclusion Criteria:

• At least 18 years of age.

  • Understand your rights as a research subject and give written informed consent by signing the Informed Consent Form, Subject Bill of Rights, and Patient Authorization for Use and Release of Health and Research Study Information (HIPAA form).
  • Be likely to finish the entire study, understand the study instructions, and be willing to follow the instructions.
  • Contact lens prescription between +4.00 D to -9.00 D (spherical equivalent).
  • Best correctable visual acuity of at least 20/40 in each eye.
  • Willing to de-adapt (do not wear) from habitual contact lenses for periods of three days prior to barrier function determination.
  • Possess a functional spectacle prescription to allow adequate vision during the de-adaptation and barrier function determination periods.
  • No known ocular or systemic allergies, which may interfere with contact lens wear.
  • No known systemic disease, or need for medication that may interfere with contact lens wear (i.e. antihistamines, beta-blockers, steroids).

Exclusion Criteria:

• Subjects demonstrating any medical condition that may affect the results of this study SHOULD NOT be enrolled. The following are specific conditions that exclude subjects from enrollment in this study.

  • Eye (ocular) or systemic allergies that may interfere with contact lens wear.
  • Less than one month successful, full time (defined as more than 8 hours per day, and more than 5 days per week) soft lens wear.
  • Systemic disease or uses of medication, which may interfere with contact lens wear.
  • Clinically significant corneal swelling (greater than grade 3 or 4 on a 0-4 scale), corneal blood vessel growth) (vascularization), corneal staining, bulbar redness, tarsal redness, or any other abnormality of the cornea that may cause unsafe contact lens wear.
  • Any active ocular infection.
  • Prior corneal refractive surgery (i.e., LASIK, PRK, etc).
  • Have used medications within 24 hours of study entry or have an ongoing need to use ocular medication.
  • Are taking part in any other study or have taken part in a study within the last 14 days
  • Have a medical condition that your study eye doctor thinks may make it not appropriate for you to participate in this study.
  • Are pregnant, or anticipate becoming pregnant during the course of this study.