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| ID | Type | Description | Link |
|---|---|---|---|
| CLCC-IORT-Sein | |||
| INCA-RECF0284 |
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RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving intraoperative radiation therapy may reduce the amount of normal tissue that needs to be removed.
PURPOSE: This phase II trial is studying how well giving radiation therapy during surgery works in treating older women with stage I breast cancer.
OBJECTIVES:
Primary
Secondary
OUTLINE: Patients undergo conservative breast surgery and axillary node dissection (sentinel node or classic resection). At this point, patients must have either negative axillary lymph nodes after removal of ≥ 6 lymph nodes, negative sentinel nodes, or have had a limited lumpectomy with negative margins ≥ 2 mm. Patients undergo intraoperative radiotherapy during surgery, before closing and reconstruction of the breast.
Patients may begin hormonal therapy after completing study therapy.
After completion of study therapy, patients are followed every 3 months for 1 year, every 4 months for 1 year, and then every 6 months for 3 years.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| treatment arm | Experimental | breast conserving surgery with lymph node dissection + Intraoperative radiotherapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| axillary lymph node dissection | Procedure |
| ||
| conventional surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Evaluation of feasibility of partial irradiation of the breast by per-operative electron therapy | feasibility based on dosimetric criteria based on the Quality Index of the application. | During the treatment of irradiation (4 weeks) |
| Evaluation of reproducibility of partial irradiation of the breast by per-operative electron therapy | reproducibility based on dosimetric criteria based on the Quality Index of the application. | During the treatment of irradiation (4 weeks) |
| Measure | Description | Time Frame |
|---|---|---|
| impact on Quality of life of partial irradiation of the breast by per-operative electron therapy | Impact described by th scores of "Instrumental Activities of Daily Living scale" | from the baseline to 12 months after the treatment |
| impact on Quality of life of partial irradiation of the breast by per-operative electron therapy |
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DISEASE CHARACTERISTICS:
Inclusion criteria:
Histologically confirmed stage I breast cancer
Hormone receptor status not specified
Exclusion criteria:
PATIENT CHARACTERISTICS:
PRIOR CONCURRENT THERAPY:
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| Name | Affiliation | Role |
|---|---|---|
| Jean-Bernard Dubois, MD | Institut du Cancer de Montpellier - Val d'Aurelle | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Regional de Lutte Contre le Cancer - Centre Val d'Aurelle | Montpellier | 34298 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 1515238 | Background | Aaronson NK. Assessing the quality of life of patients in cancer clinical trials: Common problems and common sense solutions. Eur J Cancer. 1992;28A(8-9):1304-7. doi: 10.1016/0959-8049(92)90504-u. No abstract available. | |
| 8433390 | Background | Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, Filiberti A, Flechtner H, Fleishman SB, de Haes JC, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993 Mar 3;85(5):365-76. doi: 10.1093/jnci/85.5.365. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D021701 | Sentinel Lymph Node Biopsy |
| ID | Term |
|---|---|
| D001706 | Biopsy |
| D003581 | Cytodiagnosis |
| D003584 | Cytological Techniques |
| D019411 | Clinical Laboratory Techniques |
Not provided
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partial irradiation of the breast, after an enlarged tumorectomy and negative sentinel limph node, assessing the feasibility and technical reproducibility of a per-concentrated irradiationThe first treatment was a surgical operation focused on the initial tumor area as the only treatment
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| Procedure |
|
| sentinel lymph node biopsy | Procedure |
|
| intraoperative radiation therapy | Radiation |
|
Impact described by th scores of "Activities of Daily Living scale" |
| from the baseline to 12 months after the treatment |
| Tolerability of partial irradiation of the breast by per-operative electron therapy | Tolerability done with Common Terminology Criteria for Adverse Events scale | from the baseline to 12 months after the treatment |
| Relapse-free survival | Relapse-free survival describes with radiologie evaluation | from the baseline to 12 months after the treatment |
| Disease-specific survival | Relapse-free survival describes with radiologie evaluation | from the baseline to 12 months after the treatment |
| 11535710 | Background | Nattinger AB, Kneusel RT, Hoffmann RG, Gilligan MA. Relationship of distance from a radiotherapy facility and initial breast cancer treatment. J Natl Cancer Inst. 2001 Sep 5;93(17):1344-6. doi: 10.1093/jnci/93.17.1344. No abstract available. |
| 4691036 | Background | Arnulf G. Lymphoedema of the upper limb after Halsted's operation of radical mastectomy.. Lymphography and phlebography. Therapeutic consequences. Vasc Surg. 1973 Jan-Feb;7(1):36-44. doi: 10.1177/153857447300700105. No abstract available. |
| 8622072 | Background | Arriagada R, Le MG, Rochard F, Contesso G. Conservative treatment versus mastectomy in early breast cancer: patterns of failure with 15 years of follow-up data. Institut Gustave-Roussy Breast Cancer Group. J Clin Oncol. 1996 May;14(5):1558-64. doi: 10.1200/JCO.1996.14.5.1558. |
| 11579340 | Background | Balducci L, Extermann M, Carreca I. Management of breast cancer in the older woman. Cancer Control. 2001 Sep-Oct;8(5):431-41. doi: 10.1177/107327480100800507. |
| 8995097 | Background | Balducci L, Lyman GH. Cancer in the elderly. Epidemiologic and clinical implications. Clin Geriatr Med. 1997 Feb;13(1):1-14. |
| 8637025 | Background | Ballard-Barbash R, Potosky AL, Harlan LC, Nayfield SG, Kessler LG. Factors associated with surgical and radiation therapy for early stage breast cancer in older women. J Natl Cancer Inst. 1996 Jun 5;88(11):716-26. doi: 10.1093/jnci/88.11.716. |
| 11794170 | Background | Bartelink H, Horiot JC, Poortmans P, Struikmans H, Van den Bogaert W, Barillot I, Fourquet A, Borger J, Jager J, Hoogenraad W, Collette L, Pierart M; European Organization for Research and Treatment of Cancer Radiotherapy and Breast Cancer Groups. Recurrence rates after treatment of breast cancer with standard radiotherapy with or without additional radiation. N Engl J Med. 2001 Nov 8;345(19):1378-87. doi: 10.1056/NEJMoa010874. |
| 2059815 | Background | Bates T, Riley DL, Houghton J, Fallowfield L, Baum M. Breast cancer in elderly women: a Cancer Research Campaign trial comparing treatment with tamoxifen and optimal surgery with tamoxifen alone. The Elderly Breast Cancer Working Party. Br J Surg. 1991 May;78(5):591-4. doi: 10.1002/bjs.1800780523. |
| 4962239 | Background | Brenier JL. The role of the Halsted operation in treatment of breast cancer. Int Surg. 1967 Mar;47(3):288-90. No abstract available. |
| 8482628 | Background | Buchholz TA, Austin-Seymour MM, Moe RE, Ellis GK, Livingston RB, Pelton JG, Griffin TW. Effect of delay in radiation in the combined modality treatment of breast cancer. Int J Radiat Oncol Biol Phys. 1993 Apr 30;26(1):23-35. doi: 10.1016/0360-3016(93)90169-v. |
| 8931610 | Background | Clark RM, Whelan T, Levine M, Roberts R, Willan A, McCulloch P, Lipa M, Wilkinson RH, Mahoney LJ. Randomized clinical trial of breast irradiation following lumpectomy and axillary dissection for node-negative breast cancer: an update. Ontario Clinical Oncology Group. J Natl Cancer Inst. 1996 Nov 20;88(22):1659-64. doi: 10.1093/jnci/88.22.1659. |
| 7860388 | Background | Cooke AL, Perera F, Fisher B, Opeitum A, Yu N. Tamoxifen with and without radiation after partial mastectomy in patients with involved nodes. Int J Radiat Oncol Biol Phys. 1995 Feb 15;31(4):777-81. doi: 10.1016/0360-3016(94)00499-4. |
| 10749910 | Background | Diab SG, Elledge RM, Clark GM. Tumor characteristics and clinical outcome of elderly women with breast cancer. J Natl Cancer Inst. 2000 Apr 5;92(7):550-6. doi: 10.1093/jnci/92.7.550. |
| 12346113 | Background | Dinh QC. [The population of France up to 2050]. Econ Stat. 1994;(274):7-32, 93, 95,. French. |
| 8695261 | Background | Fentiman IS, Poole C, Tong D, Winter PJ, Gregory WM, Mayles HM, Turner P, Chaudary MA, Rubens RD. Inadequacy of iridium implant as sole radiation treatment for operable breast cancer. Eur J Cancer. 1996 Apr;32A(4):608-11. doi: 10.1016/0959-8049(95)00639-7. |
| 1827719 | Background | Fentiman IS, Poole C, Tong D, Winter PJ, Mayles HM, Turner P, Chaudary MA, Rubens RD. Iridium implant treatment without external radiotherapy for operable breast cancer: a pilot study. Eur J Cancer. 1991;27(4):447-50. doi: 10.1016/0277-5379(91)90383-o. |
| 7477145 | Background | Fisher B, Anderson S, Redmond CK, Wolmark N, Wickerham DL, Cronin WM. Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med. 1995 Nov 30;333(22):1456-61. doi: 10.1056/NEJM199511303332203. |
| 8197778 | Background | Fisher B, Anderson S. Conservative surgery for the management of invasive and noninvasive carcinoma of the breast: NSABP trials. National Surgical Adjuvant Breast and Bowel Project. World J Surg. 1994 Jan-Feb;18(1):63-9. doi: 10.1007/BF00348193. |
| 8292119 | Background | Fisher B, Costantino J, Redmond C, Fisher E, Margolese R, Dimitrov N, Wolmark N, Wickerham DL, Deutsch M, Ore L, et al. Lumpectomy compared with lumpectomy and radiation therapy for the treatment of intraductal breast cancer. N Engl J Med. 1993 Jun 3;328(22):1581-6. doi: 10.1056/NEJM199306033282201. |
| 2927449 | Background | Fisher B, Redmond C, Poisson R, Margolese R, Wolmark N, Wickerham L, Fisher E, Deutsch M, Caplan R, Pilch Y, et al. Eight-year results of a randomized clinical trial comparing total mastectomy and lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med. 1989 Mar 30;320(13):822-8. doi: 10.1056/NEJM198903303201302. |
| 8806289 | Background | Forrest AP, Stewart HJ, Everington D, Prescott RJ, McArdle CS, Harnett AN, Smith DC, George WD. Randomised controlled trial of conservation therapy for breast cancer: 6-year analysis of the Scottish trial. Scottish Cancer Trials Breast Group. Lancet. 1996 Sep 14;348(9029):708-13. doi: 10.1016/s0140-6736(96)02133-2. |
| 7860374 | Background | Fowble B. An assessment of treatment options for breast conservation in the elderly woman with early stage breast cancer. Int J Radiat Oncol Biol Phys. 1995 Feb 15;31(4):1015-7. doi: 10.1016/0360-3016(95)00008-9. No abstract available. |
| 8181594 | Background | Gazet JC, Ford HT, Coombes RC, Bland JM, Sutcliffe R, Quilliam J, Lowndes S. Prospective randomized trial of tamoxifen vs surgery in elderly patients with breast cancer. Eur J Surg Oncol. 1994 Jun;20(3):207-14. |
| 9802618 | Background | Gruenberger T, Gorlitzer M, Soliman T, Rudas M, Mittlboeck M, Gnant M, Reiner A, Teleky B, Seitz W, Jakesz R. It is possible to omit postoperative irradiation in a highly selected group of elderly breast cancer patients. Breast Cancer Res Treat. 1998 Jul;50(1):37-46. doi: 10.1023/a:1006064608360. |
| 11163516 | Background | Harms W, Krempien R, Hensley FW, Berns C, Wannenmacher M, Fritz P. Results of chest wall reirradiation using pulsed-dose-rate (PDR) brachytherapy molds for breast cancer local recurrences. Int J Radiat Oncol Biol Phys. 2001 Jan 1;49(1):205-10. doi: 10.1016/s0360-3016(00)01360-2. |
| 10091795 | Background | Hebert-Croteau N, Brisson J, Latreille J, Blanchette C, Deschenes L. Compliance with consensus recommendations for the treatment of early stage breast carcinoma in elderly women. Cancer. 1999 Mar 1;85(5):1104-13. |
| 2153190 | Background | Holland R, Connolly JL, Gelman R, Mravunac M, Hendriks JH, Verbeek AL, Schnitt SJ, Silver B, Boyages J, Harris JR. The presence of an extensive intraductal component following a limited excision correlates with prominent residual disease in the remainder of the breast. J Clin Oncol. 1990 Jan;8(1):113-8. doi: 10.1200/JCO.1990.8.1.113. |
| 2990668 | Background | Holland R, Veling SH, Mravunac M, Hendriks JH. Histologic multifocality of Tis, T1-2 breast carcinomas. Implications for clinical trials of breast-conserving surgery. Cancer. 1985 Sep 1;56(5):979-90. doi: 10.1002/1097-0142(19850901)56:53.0.co;2-n. |
| 7877647 | Background | Jacobson JA, Danforth DN, Cowan KH, d'Angelo T, Steinberg SM, Pierce L, Lippman ME, Lichter AS, Glatstein E, Okunieff P. Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med. 1995 Apr 6;332(14):907-11. doi: 10.1056/NEJM199504063321402. |
| 3403309 | Background | Kantorowitz DA, Poulter CA, Sischy B, Paterson E, Sobel SH, Rubin P, Dvoretsky PA, Mishalak W, Doane KL. Treatment of breast cancer among elderly women with segmental mastectomy or segmental mastectomy plus postoperative radiotherapy. Int J Radiat Oncol Biol Phys. 1988 Aug;15(2):263-70. doi: 10.1016/s0360-3016(98)90003-7. |
| 5420677 | Background | Katz S, Downs TD, Cash HR, Grotz RC. Progress in development of the index of ADL. Gerontologist. 1970 Spring;10(1):20-30. doi: 10.1093/geront/10.1_part_1.20. No abstract available. |
| 14044222 | Background | KATZ S, FORD AB, MOSKOWITZ RW, JACKSON BA, JAFFE MW. STUDIES OF ILLNESS IN THE AGED. THE INDEX OF ADL: A STANDARDIZED MEASURE OF BIOLOGICAL AND PSYCHOSOCIAL FUNCTION. JAMA. 1963 Sep 21;185:914-9. doi: 10.1001/jama.1963.03060120024016. No abstract available. |
| 11113440 | Background | King TA, Bolton JS, Kuske RR, Fuhrman GM, Scroggins TG, Jiang XZ. Long-term results of wide-field brachytherapy as the sole method of radiation therapy after segmental mastectomy for T(is,1,2) breast cancer. Am J Surg. 2000 Oct;180(4):299-304. doi: 10.1016/s0002-9610(00)00454-2. |
| 5349366 | Background | Lawton MP, Brody EM. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist. 1969 Autumn;9(3):179-86. No abstract available. |
| 8523054 | Background | Leonard CE, Wood ME, Zhen B, Rankin J, Waitz DA, Norton L, Howell K, Sedlacek S. Does administration of chemotherapy before radiotherapy in breast cancer patients treated with conservative surgery negatively impact local control? J Clin Oncol. 1995 Dec;13(12):2906-15. doi: 10.1200/JCO.1995.13.12.2906. |
| 10561294 | Background | Liljegren G, Holmberg L, Bergh J, Lindgren A, Tabar L, Nordgren H, Adami HO. 10-Year results after sector resection with or without postoperative radiotherapy for stage I breast cancer: a randomized trial. J Clin Oncol. 1999 Aug;17(8):2326-33. doi: 10.1200/JCO.1999.17.8.2326. |
| 6870379 | Background | Maddox WA, Carpenter JT Jr, Laws HL, Soong SJ, Cloud G, Urist MM, Balch CM. A randomized prospective trial of radical (Halsted) mastectomy versus modified radical mastectomy in 311 breast cancer patients. Ann Surg. 1983 Aug;198(2):207-12. doi: 10.1097/00000658-198308000-00016. |
| 9413955 | Background | Macquart-Moulin G, Viens P, Bouscary ML, Genre D, Resbeut M, Gravis G, Camerlo J, Maraninchi D, Moatti JP. Discordance between physicians' estimations and breast cancer patients' self-assessment of side-effects of chemotherapy: an issue for quality of care. Br J Cancer. 1997;76(12):1640-5. doi: 10.1038/bjc.1997.610. |
| 10326697 | Background | Macquart-Moulin G, Viens P, Genre D, Bouscary ML, Resbeut M, Gravis G, Camerlo J, Maraninchi D, Moatti JP. Concomitant chemoradiotherapy for patients with nonmetastatic breast carcinoma: side effects, quality of life, and organization. Cancer. 1999 May 15;85(10):2190-9. |
| 10931455 | Background | Mandelblatt JS, Hadley J, Kerner JF, Schulman KA, Gold K, Dunmore-Griffith J, Edge S, Guadagnoli E, Lynch JJ, Meropol NJ, Weeks JC, Winn R. Patterns of breast carcinoma treatment in older women: patient preference and clinical and physical influences. Cancer. 2000 Aug 1;89(3):561-73. |
| 8385722 | Background | Morimoto T, Okazaki K, Komaki K, Sasa M, Mori T, Tsuzuki H, Kamamura Y, Miki H, Monden Y. Cancerous residue in breast-conserving surgery. J Surg Oncol. 1993 Feb;52(2):71-6. doi: 10.1002/jso.2930520203. |
| 1190875 | Background | Nemoto T, Dao TL. Is modified radical mastectomy adequate for axillary lymph node dissection? Ann Surg. 1975 Dec;182(6):722-3. doi: 10.1097/00000658-197512000-00011. |
| 1848474 | Background | Nemoto T, Patel JK, Rosner D, Dao TL, Schuh M, Penetrante R. Factors affecting recurrence in lumpectomy without irradiation for breast cancer. Cancer. 1991 Apr 15;67(8):2079-82. doi: 10.1002/1097-0142(19910415)67:83.0.co;2-s. |
| 10832826 | Background | Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials. Early Breast Cancer Trialists' Collaborative Group. Lancet. 2000 May 20;355(9217):1757-70. |
| 9274791 | Background | Perera F, Engel J, Holliday R, Scott L, Girotti M, Girvan D, Chisela F, Venkatesan V. Local resection and brachytherapy confined to the lumpectomy site for early breast cancer: a pilot study. J Surg Oncol. 1997 Aug;65(4):263-7; discussion 267-8. doi: 10.1002/(sici)1096-9098(199708)65:43.0.co;2-3. |
| 4950576 | Background | Ravitch MM. Carcinoma of the breast: the place of the Halsted radical mastectomy. Johns Hopkins Med J. 1971 Oct;129(4):202-11. No abstract available. |
| 2804582 | Background | Reed MW, Morrison JM. Wide local excision as the sole primary treatment in elderly patients with carcinoma of the breast. Br J Surg. 1989 Sep;76(9):898-900. doi: 10.1002/bjs.1800760908. |
| 9060534 | Background | Romestaing P, Lehingue Y, Carrie C, Coquard R, Montbarbon X, Ardiet JM, Mamelle N, Gerard JP. Role of a 10-Gy boost in the conservative treatment of early breast cancer: results of a randomized clinical trial in Lyon, France. J Clin Oncol. 1997 Mar;15(3):963-8. doi: 10.1200/JCO.1997.15.3.963. |
| 8423623 | Background | Silliman RA, Balducci L, Goodwin JS, Holmes FF, Leventhal EA. Breast cancer care in old age: what we know, don't know, and do. J Natl Cancer Inst. 1993 Feb 3;85(3):190-9. doi: 10.1093/jnci/85.3.190. |
| 2702835 | Background | Simon R. Optimal two-stage designs for phase II clinical trials. Control Clin Trials. 1989 Mar;10(1):1-10. doi: 10.1016/0197-2456(89)90015-9. |
| 11369068 | Background | Sminia P, Schneider CJ, van Tienhoven G, Koedooder K, Blank LE, Gonzalez Gonzalez D. Office hours pulsed brachytherapy boost in breast cancer. Radiother Oncol. 2001 Jun;59(3):273-80. doi: 10.1016/s0167-8140(01)00335-8. |
| 11121624 | Background | Smith TE, Lee D, Turner BC, Carter D, Haffty BG. True recurrence vs. new primary ipsilateral breast tumor relapse: an analysis of clinical and pathologic differences and their implications in natural history, prognoses, and therapeutic management. Int J Radiat Oncol Biol Phys. 2000 Dec 1;48(5):1281-9. doi: 10.1016/s0360-3016(00)01378-x. |
| 7642430 | Background | Solin LJ, Schultz DJ, Fowble BL. Ten-year results of the treatment of early-stage breast carcinoma in elderly women using breast-conserving surgery and definitive breast irradiation. Int J Radiat Oncol Biol Phys. 1995 Aug 30;33(1):45-51. doi: 10.1016/0360-3016(95)00104-7. |
| 8874337 | Background | Sprangers MA, Groenvold M, Arraras JI, Franklin J, te Velde A, Muller M, Franzini L, Williams A, de Haes HC, Hopwood P, Cull A, Aaronson NK. The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study. J Clin Oncol. 1996 Oct;14(10):2756-68. doi: 10.1200/JCO.1996.14.10.2756. |
| 11583188 | Background | Vaidya JS, Baum M, Tobias JS, D'Souza DP, Naidu SV, Morgan S, Metaxas M, Harte KJ, Sliski AP, Thomson E. Targeted intra-operative radiotherapy (Targit): an innovative method of treatment for early breast cancer. Ann Oncol. 2001 Aug;12(8):1075-80. doi: 10.1023/a:1011609401132. |
| 10904087 | Background | van Dongen JA, Voogd AC, Fentiman IS, Legrand C, Sylvester RJ, Tong D, van der Schueren E, Helle PA, van Zijl K, Bartelink H. Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst. 2000 Jul 19;92(14):1143-50. doi: 10.1093/jnci/92.14.1143. |
| 7015141 | Background | Veronesi U, Saccozzi R, Del Vecchio M, Banfi A, Clemente C, De Lena M, Gallus G, Greco M, Luini A, Marubini E, Muscolino G, Rilke F, Salvadori B, Zecchini A, Zucali R. Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med. 1981 Jul 2;305(1):6-11. doi: 10.1056/NEJM198107023050102. |
| 8387637 | Background | Veronesi U, Luini A, Del Vecchio M, Greco M, Galimberti V, Merson M, Rilke F, Sacchini V, Saccozzi R, Savio T, et al. Radiotherapy after breast-preserving surgery in women with localized cancer of the breast. N Engl J Med. 1993 Jun 3;328(22):1587-91. doi: 10.1056/NEJM199306033282202. |
| 11521809 | Background | Veronesi U, Marubini E, Mariani L, Galimberti V, Luini A, Veronesi P, Salvadori B, Zucali R. Radiotherapy after breast-conserving surgery in small breast carcinoma: long-term results of a randomized trial. Ann Oncol. 2001 Jul;12(7):997-1003. doi: 10.1023/a:1011136326943. |
| 9989418 | Background | Vicini F, Kini VR, Chen P, Horwitz E, Gustafson G, Benitez P, Edmundson G, Goldstein N, McCarthy K, Martinez A. Irradiation of the tumor bed alone after lumpectomy in selected patients with early-stage breast cancer treated with breast conserving therapy. J Surg Oncol. 1999 Jan;70(1):33-40. doi: 10.1002/(sici)1096-9098(199901)70:13.0.co;2-o. |
| 11283132 | Background | Vicini FA, Baglan KL, Kestin LL, Mitchell C, Chen PY, Frazier RC, Edmundson G, Goldstein NS, Benitez P, Huang RR, Martinez A. Accelerated treatment of breast cancer. J Clin Oncol. 2001 Apr 1;19(7):1993-2001. doi: 10.1200/JCO.2001.19.7.1993. |
| 11320515 | Background | Vicini FA, Kestin LL, Goldstein NS, Baglan KL, Pettinga JE, Martinez AA. Relationship between excision volume, margin status, and tumor size with the development of local recurrence in patients with ductal carcinoma-in-situ treated with breast-conserving therapy. J Surg Oncol. 2001 Apr;76(4):245-54. doi: 10.1002/jso.1041. |
| 11571720 | Background | Vlastos G, Mirza NQ, Meric F, Hunt KK, Kuerer HM, Ames FC, Ross MI, Buchholz TA, Hortobagyi GN, Singletary SE. Breast conservation therapy as a treatment option for the elderly. The M. D. Anderson experience. Cancer. 2001 Sep 1;92(5):1092-100. doi: 10.1002/1097-0142(20010901)92:53.0.co;2-p. |
| 8273979 | Background | von Rueden DG, Sessions SC. Alternative therapy for elderly patients with breast cancer. Am Surg. 1994 Jan;60(1):72-8. |
| 4916652 | Background | William Stewart Halsted (1852-1922) surgeon of the "Hopkins Four". JAMA. 1970 Sep 21;213(12):2072-4. No abstract available. |
| D017437 |
| Skin and Connective Tissue Diseases |
| D019937 |
| Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D013048 | Specimen Handling |
| D003949 | Diagnostic Techniques, Surgical |
| D013514 | Surgical Procedures, Operative |
| D008197 | Lymph Node Excision |
| D008919 | Investigative Techniques |