A 3 month, randomized, open label, multi-center study of Technosphere/Insulin compared to insulin aspart in subjects with type 1 diabetes mellitus receiving insulin glargine

Inclusion Criteria:

• Type 1 diabetes currently receiving SC insulin at mealtimes for at least 3 months
• BMI <40 kg/m squared
• HbA1c greater than or equal to 7% and less than or equal to 11.5%
• Serum creatinine less than 2 for males and less than 1.8 for females
• Acceptable pulmonary function

Exclusion Criteria:

• Significant hepatic disease
• Previously diagnosed pulmonary disease, ketoacidosis of evidence of severe secondary complications of diabetes