Simvatstatin Used to Treat Pulmonary Hypertension

the Clinical Research Using Simvastatin as a Medication to Treat Advanced Secondary Pulmonary Hypertension

we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.

advanced pulmonary hypertension is refractory to the medication in use nowaday, especially pulmonary hypertension secondary to congenital heart disease or chronic pulmonary embolism.It is revealed that statins may intefere the pathogenisis of the pulmonary hypertension in many key poing, such as improving apotosis or inhiting the proliferation of pulmonary vascular smooth muscle cell. so we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.

Inclusion Criteria:

• pasp>50mmHg

Exclusion Criteria:

• pasp<50mmhg