Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery

A Study of Simvastatin on Myocardial Protection and Cardiac Function Undergoing Cardiac Surgery With Cardiopulmonary Bypass

Statins have been used to low cholesterol to prevent and treat coronary artery diseases. It was also reported that statins could protect endothelial function and cardiac function during coronary artery bypass graft. The investigators recent found simvastatin reduced myocardial injury during noncoronary artery cardiac surgery in single medical center. The investigators further investigate that whether simvastatin can protect myocardium during noncoronary artery cardiac surgery with cardiopulmonary bypass and improve cardiac function with long term use postoperatively in two medical centers.

Inclusion Criteria:

• More than 18-year-old,
• Congenital heart disease(not complex),
• Isolated heart valve disease,

Exclusion Criteria:

• Coronary artery disease
• Allergy for statins
• Poor liver function,Hepatitis
• Gestation women and Breast-feeding women