Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism

Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism,a Double Blind Randomized Cross-Over Study.

To compare the effect of T4-T3 combination therapy versus T4 monotherapy in patients with autoimmune hypothyroidism, on stable T4-substitution therapy

double blind randomized cross-over study.

Inclusion Criteria:

• Hypothyroidism, S-TSH> 20 at diagnosis,Anti-TPO >300 Normal TSH (0,4-4,0) for 6 months.

Exclusion Criteria:

• <18 år
• >75 år
• pregnant women
• Thyroid cancer
• T3 treatment
• Post-partum thyroiditis