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| Name | Class |
|---|---|
| University of San Francisco | OTHER |
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The primary objective of this study is to evaluate the learnability of a 3 week, 40 minutes per day, 5 day per week, computer-based visual training exercise by healthy mature individuals undergoing normal aging.
Virtually all adults will suffer a decline in their cognitive capacities to some degree. Typically, cognitive decline is characterized by a slow, progressive decline in abilities (frequently in memory, attention, inhibition and speed of processing) relative to younger adults, commonly called normal aging, age-associated memory impairment, age-consistent memory impairment, benign senescent forgetfulness, late-life forgetfulness, ageing-associated cognitive decline, and the preferred term, age-related cognitive decline (ARCD) As virtually all adults experience a reduction in their cognitive abilities with age, ARCD has generally been considered to be a normal, inevitable, and irreversible part of aging; and the extremely severe forms of pathological cognitive decline (e.g., Alzheimer's disease, AD) have dominated therapeutic research in this area. However, ARCD represents an important cause of quality of life decline in almost every older adult, as the impact of forgetfulness and mental slowing increasingly change the abilities of individuals to successfully manage their day-to-day activities. Therapeutic approaches targeting the specific problems of ARCD in normal aging (as opposed to the pathological problems of AD) would unto themselves represent important clinical advances.
This trial investigates the effects of a computer-based visual training exercise built on the principles of positive brain plasticity and designed for use by healthy mature individuals. The program is specifically designed to improve the fidelity of sensory representations in early visual cortex.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| I | No Intervention | No contact control (NCC) | |
| II | Experimental | Computerized, SAAGE-designed, visual memory-based cognitive training |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SAAGE-designed, visual memory-based cognitive training | Behavioral | Training sessions take 40 minutes per day, five days per week for a total goal of 15, 40-minute sessions. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Improvement in visual memory assessment after training or no-contact period. | 6-8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Improvement on at least 1 of the Computerized Visual Attention, Speed and Memory Tests conducted. | 6-8 weeks | |
| Improvement on the computerized cognitive assessments. | 6-8 weeks | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Daniel Tinker, BS | Contact | 4153943100 | 3541 | daniel.tinker@positscience.com |
| Cate Stasio, BA | Contact | 4153943100 | 3546 | cate.stasio@positscience.com |
| Name | Affiliation | Role |
|---|---|---|
| Joseph L Hardy, PhD | Posit Science Corporation | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Posit Science Corporation | Recruiting | San Francisco Bay Area | California | 94104 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 12392483 | Background | Bischkopf J, Busse A, Angermeyer MC. Mild cognitive impairment--a review of prevalence, incidence and outcome according to current approaches. Acta Psychiatr Scand. 2002 Dec;106(6):403-14. doi: 10.1034/j.1600-0447.2002.01417.x. | |
| 12108606 | Background | Fillit HM, Butler RN, O'Connell AW, Albert MS, Birren JE, Cotman CW, Greenough WT, Gold PE, Kramer AF, Kuller LH, Perls TT, Sahagan BG, Tully T. Achieving and maintaining cognitive vitality with aging. Mayo Clin Proc. 2002 Jul;77(7):681-96. doi: 10.4065/77.7.681. |
| Label | URL |
|---|---|
| Click here for more information about computerized cognitive training | View source |
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| Type | Date | Date Unknown |
|---|---|---|
| Release | May 15, 2013 | |
| Reset | Jul 2, 2013 | |
| Release | Nov 12, 2013 | |
| Reset | Dec 26, 2013 | |
| Release | Feb 21, 2019 | |
| Unrelease | Feb 21, 2019 |
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| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| May 15, 2013 | Jul 2, 2013 | |||
| Nov 12, 2013 |
| ID | Term |
|---|---|
| D060825 | Cognitive Dysfunction |
| ID | Term |
|---|---|
| D003072 | Cognition Disorders |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
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|
| Improvement on exercise-based assessments. |
| 6-8 weeks |
| 11698688 | Background | Ahissar E, Nagarajan S, Ahissar M, Protopapas A, Mahncke H, Merzenich MM. Speech comprehension is correlated with temporal response patterns recorded from auditory cortex. Proc Natl Acad Sci U S A. 2001 Nov 6;98(23):13367-72. doi: 10.1073/pnas.201400998. |
| 14677145 | Background | Park HL, O'Connell JE, Thomson RG. A systematic review of cognitive decline in the general elderly population. Int J Geriatr Psychiatry. 2003 Dec;18(12):1121-34. doi: 10.1002/gps.1023. |
| 15324603 | Background | Scarmeas N, Stern Y. Cognitive reserve: implications for diagnosis and prevention of Alzheimer's disease. Curr Neurol Neurosci Rep. 2004 Sep;4(5):374-80. doi: 10.1007/s11910-004-0084-7. |
| Dec 26, 2013 |
| Feb 21, 2019 | Feb 21, 2019 |