Do Antidepressants Induce Metabolic Syndromes METADAP Study

Do Antidepressants Induce Metabolic Syndromes

Since antidepressants and antipsychotics have common receptorial mechanisms of action (H1 antagonism, 5HT2 antagonism), the impact of antidepressants in terms of metabolic syndromes is a matter of concern.

The main objective of this study is to assess the differential impact of antidepressants in terms of weight gain and metabolic syndromes.

Since antidepressants and antipsychotics have common receptorial mechanisms of action (H1 antagonism, 5HT2 antagonism), the impact of antidepressants in terms of metabolic syndromes is a matter of concern.

The main objective of this study is to assess the differential impact of antidepressants in terms of weight gain and metabolic syndromes.

Prospective 6-month naturalistic cohort study, comparing 4 classes of antidepressants (SSRIs, SNRIs, TCAs and others) to a control group (ECT and r-TMS), in 600 patients with a major depressive disorder requiring the beginning of either antidepressant or ECT/r-TMS treatment.

Inclusion Criteria:

• Age : 18-70
• Current major depressive episode (Major depressive disorder) based on the MINI interview
• HAM-D >18
• Requiring either antidepressant treatment, either ECT or r-TMS (as assessed by the clinician)
• Signed informed consent

Exclusion Criteria:

• Bipolar disorder (DSM-IV), Psychotic disorder (DSM-IV), Substance abuse or dependence (DSM-IV)
• Normothymic treatment
• Antipsychotic treatment