Proteomics of Severe Traumatic Brain Injury: A Feasibility Study

Proteomics of Severe Traumatic Brain Injury: A Feasibility Study

The purpose of this study is to:

1. Determine the temporal course of matrix metalloproteinase (MMP) expression in patients wiht severe traumatic brain injury
2. Determine the temporal course of the expression of MMP-related inflammatory mediators of secondary injury in patients with severe traumatic brain injury
3. Describe the association of physiological changes and standard microdialysis analyte measures (lactate, pyruvate, lactate/pyruvate ratio, and glucose) to MMP and neuroinflammatory marker concentrations.

Inclusion Criteria:

• Patient is 18 years of age or older
• Patient has GCS less than 9
• Patient requires intracranial pressure monitoring
• Patient life expectancy greater than 72 hours

Exclusion Criteria:

• Patient's TBI is greater than 24 hours old
• Patient is less than 18 years of age
• Patient does not require intracranial pressure monitoring
• Patient has life expectancy less than 72 hours
• Patient has GCS greater or equal to 9
• Patient is currently enrolled in another study