Asymptomatic Primary Hyperparathyroidism: A Prospective, Randomized Trial

Asymptomatic Primary Hyperparathyroidism: A Prospective, Randomized Trial

The present study is a randomized, controlled trial that investigates the effects of parathyroidectomy or medical observation in mild asymptomatic pHPT on morbidity and quality of life (QoL).

The patients are included and randomized by block randomization to medical observation or parathyroidectomy by an experienced parathyroid surgeon.

The patients will be followed up for 10 years.

Inclusion Criteria:

• Untreated, asymptomatic pHPT
• 2.60>S-Ca<2.85 mmol/liter
• Age between 50 and 80 yr
• No medications interfering with Ca-metabolism
• Informed consent

Exclusion Criteria:

• Hyperparathyroid bone disease
• Previous operation in the neck
• Impaired kidney function
• Kidney stones
• Complicating medical conditions
• Psychiatric disorders
• Multiple endocrine neoplasia,
• Familial hypocalcuric hypercalcemia
• Familial HPT