Role of Volatile Anesthetics for Hepatic Protection

Role of Volatile Anesthetics for Hepatic Protection in Ischemia-reperfusion

This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of liver enzymes, reduced production of inflammatory mediators).

Organ protection; preconditioning; volatile anesthetics; ischemia reperfusion

Inclusion Criteria:

• Older than 18 years of age
• Patients undergoing liver resection (benign or malignant tumors)

Exclusion Criteria:

• Laparoscopic liver resection coagulopathy (platelets < 50,000/ml, Quick < 50%)
• Liver cirrhosis