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This study will be conducted in healthy volunteers to investigate the effect of single dose GSK561679 on the changes of brain activation, as it compares to an active comparator, lorazepam.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| placebo arm | Placebo Comparator | There are single dose treatment arms of GSK561679, lorazepam as well as placebo. |
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| GSK561679 arm | Experimental | There are single dose treatment arms of GSK561679, lorazepam as well as placebo. |
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| lorazepam arm | Active Comparator | There are single dose treatment arms of GSK561679, lorazepam as well as placebo. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| single dose | Drug | Subjects will receive single doses of GSK561679, lorazepam, or placebo at each treatment session. |
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| Measure | Description | Time Frame |
|---|---|---|
| Differences in fMRI brain activation (BOLD) response in specific brain regions | conducted the duration of the study |
| Measure | Description | Time Frame |
|---|---|---|
| Physiologic changes | during & after fMRI session | |
| Visual Analogue Scale measurement of physical reactions | duration of study | |
| Blood level of GSK561679 |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| GSK Clinical Trials | GlaxoSmithKline | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| GSK Investigational Site | La Jolla | California | 92037 | United States |
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| Label | URL |
|---|---|
| Results for study CRS105510 can be found on the GSK Clinical Study Register. | View source |
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| ID | Term |
|---|---|
| D003866 | Depressive Disorder |
| D001008 | Anxiety Disorders |
| ID | Term |
|---|---|
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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| collected during fMRI session |
| Vital signs & ECG recording | duration of the study |
| Lab tests for blood & urine | throughout the study |