fMRI Study Comparing BOLD Activation Patterns Using GW679769 In Subjects With Social Anxiety Disorder

A Double-Blind, Randomized, Placebo-Controlled, Double-Dummy, Parallel Group, fMRI Study Comparing BOLD Activation Patterns Before and After 12 Weeks of Treatment With Placebo, Comparator and GW679769 in Subjects With Social Anxiety Disorder (SAD).

Evidence suggests the use of neuroimaging to detect therapeutic effects of anxiolytic treatment when appropriate cognitive-emotional tasks are use to activate the emotional brain neurocircuitry believed to be involved in the core symptoms of the disease.

Inclusion criteria:

• Primary diagnosis of Social Anxiety Disorder.
• Willing to restrict alcohol to a limited intake.

Exclusion criteria:

• History of schizophrenia, schizoaffective disorder or a bipolar disorder.
• Left-handed.
• Suffer from claustrophobia.
• Any reason why subject could not go into the fMRI, for example have metal implants.