The purpose of this study is to verify whether the reduction of cyclosporine dosages associated with Everolimus administration may improve renal function as compared to patients maintained on standard immunosuppressive therapy

Inclusion Criteria:

• Heart Transplant patients with more than 1 year of follow-up
• Creatinine lower than 3.5 mg/dl
• GFR Higher than 20 ml/min (calculated with Cockcroft-Gault formula)
• Cyclosporine in maintenance immunosuppressive therapy
• Patient must be able to sign an approve informed consent
• Prior History of acute rejection within the last 3 months
• Females of childbearing age may be included if pregnancy is excluded and acceptable contraception measures are used

Exclusion Criteria:

• Patients who are recipients of multiple organ transplants
• Prior or current use of sirolimus or everolimus
• History of acute rejection within the last 6 months
• Coronary Artery Bypass Surgery or other cardiac surgery in the past 3 months
• Patient not able to attend all follow-up evaluations