Duloxetine Versus Paroxetine for Major Depression

Duloxetine Versus Paroxetine in the Acute Treatment of Major Depression

To determine if duloxetine works just as well as paroxetine in the treatment of major depressive disorder.

Inclusion Criteria:

• You are male or female at least 18 years of age with nonpsychotic major depression. Females of child-bearing potential must test negative on a pregnancy test at visit 1.

Exclusion Criteria:

• You have a serious medical illness, including any cardiovascular, hepatic, renal, respiratory, hematologic, endocrinologic, or neurologic disease, or clinically significant laboratory abnormality.
• You have a history of hepatic dysfunction, current jaundice, or positive hepatitis B surface Antigen or positive hepatitis C surface Antibody regardless of ALT.
• You have an ALT greater than or equal to 2 times the upper limit of normal.
• You have abnormal thyroid-stimulating hormone concentrations.