Duloxetine vs. Active Comparator for the Treatment of Depression

Duloxetine Versus Venlafaxine Extended Release in the Treatment of Major Depressive Disorder

How duloxetine compares to a medication currently available for the treatment of depression in the treatment of patients with major depressive disorder.

The safety of duloxetine and any side effects that might be associated with it.

Inclusion Criteria:

• must be at least 18 years of age
• must be diagnosed with depression
• must sign informed consent

Exclusion Criteria:

• women who can become pregnant must be using birth control
• previous diagnosis of bipolar disorder, schizophrenia, or other psychotic disorder
• history of substance abuse or dependence in the last year
• patients who are suicidal
• frequent or severe allergic reactions with multiple medications