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| Name | Class |
|---|---|
| Aarhus University Hospital | OTHER |
| Pfizer | INDUSTRY |
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The purpose of this study is to examine the effects of growth hormone during fasting in healthy lean men.
During fasting the human body is known to metabolize relatively large amounts of fat, in the expense of proteins and glucose. Partly this shift in metabolism is caused by increasing GH secretion, but exactly how growth hormone exerts these effects remains to be further investigated.
10 healthy lean young men are studied at 4 different occasions in a randomized single-blinded cross-over study. 1: after 12 hours of fasting + GH bolus, 2: after 36 hours of fasting + GH bolus, 3: after 36 hours + saline, 4: after 36 hours of fasting + Somavert.
Aim:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| 1 | Experimental | 12 hours of fasting and a GH bolus |
|
| 2 | Experimental | 36 hours of fasting and a GH bolus |
|
| 3 | Experimental | 36 hours of fasting and Pegvisomant |
|
| 4 | Experimental | 36 hours of fasting and NaCl injection |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Somatropin and pegvisomant | Drug | Somatropin are given intravenous, 0.5mg pegvisomant are given subcutaneous, 15 mg NaCl are given subcutaneous, 2 ml |
|
| Measure | Description | Time Frame |
|---|---|---|
| changes in intrahepatic lipid content | 12 and 36 hours of fasting. respectively | |
| changes in intracellular signaling during fasting | 36 hours | |
| changes in respiratory quotient | 36 hours of fasting | |
| metabolism | 36 hours of fasting | |
| insulin sensitivity | 36 hours of fasting | |
| forearm metabolism | 36 hours of fasting |
| Measure | Description | Time Frame |
|---|---|---|
| changes in FFA | 36 hours of fasting | |
| Changes in grelin | 36 hours of fasting | |
| changes in leptin, adiponektin, cortisol, catecholamine, glucagon, carbamide, palmitate |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Louise Moller, MD | Medical department M, Aarhus Sygehus, Norrebrogade 44, 8000 Aarhus, Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Medical department M, Arhus Sygehus, Region midtjylland | Aarhus | 8000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 19820031 | Derived | Moller L, Norrelund H, Jessen N, Flyvbjerg A, Pedersen SB, Gaylinn BD, Liu J, Thorner MO, Moller N, Lunde Jorgensen JO. Impact of growth hormone receptor blockade on substrate metabolism during fasting in healthy subjects. J Clin Endocrinol Metab. 2009 Nov;94(11):4524-32. doi: 10.1210/jc.2009-0381. Epub 2009 Oct 9. |
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| ID | Term |
|---|---|
| D005234 | Fatty Liver |
| D005215 | Fasting |
| D007333 | Insulin Resistance |
| ID | Term |
|---|---|
| D008107 | Liver Diseases |
| D004066 | Digestive System Diseases |
| D005247 | Feeding Behavior |
| D001519 | Behavior |
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| ID | Term |
|---|---|
| D019382 | Human Growth Hormone |
| C406545 | pegvisomant |
| ID | Term |
|---|---|
| D013006 | Growth Hormone |
| D010908 | Pituitary Hormones, Anterior |
| D010907 | Pituitary Hormones |
| D036361 | Peptide Hormones |
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| 36 hours of fasting |
| D006946 |
| Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D006728 |
| Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D010455 | Peptides |
| D000602 | Amino Acids, Peptides, and Proteins |