Effect of Flaxseed on Lipid Uptake and Appetite

Effect of Whole Flaxseeds and Flaxseed Mucilage on Lipid Absorption, Glucose and Insulin Metabolism and Appetite Regulation

Randomized trial to test the effect of flaxseed fractions on appetite regulation and intestinal lipid absorption.

Randomized multiple crossover trial in 18 healthy males aged 18 to 40 years each are required to complete a total of five iso-caloric meal tests lasting approximately 8½ hours. Test meals will be given as breakfast meals, in which different fractions of flaxseeds are incorporated into baked products. Appetite will be registered using visual analogue scales during 7 hours after the test meal and a total of 10 blood samples will be drawn to evaluate TAG in chylomicrons, plasma LDL, HDL and total cholesterol, plasma TAG, insulin, glucose and appetite hormone levels. At the end of the test day an ad libitum meal will be served and food intake registered.

Inclusion Criteria:

• Healthy males aged 18-40 years
• Normal weight or moderately overweigh (BMI 25-30 kg/m2)

Exclusion Criteria:

• Blood drawing/donation less than six months prior to start of the study
• Hemoglobin concentration <8mmol/L
• Chronic diseases (i.e. diabetes, CVD), hypertension, hyperlipidemia
• Consumption of dietary supplements including vitamin tablets
• Smoking
• Excess physical activity (>10h of intense physical activity per week)
• Medicine use (not including occasional consumption of pain killers)