Study Evaluating the Effects of MOA-728 on Cardiac Repolarization in Healthy Subjects

A Randomized, Double-Blind, Placebo- and Moxifloxacin (Open-Label)-Controlled, 4-Period Crossover Study of the Effects of a Single Dose of MOA-728 Infused Intravenously on Cardiac Repolarization in Healthy Subjects

The purpose of the study is to assess the effects of MOA-728 on cardiac repolarization in healthy subjects.

Inclusion Criteria:

• Generally healthy subjects men or women aged 18-50

Exclusion Criteria:

• Any significant clinically important disease
• Family history of long QT syndrome and/or sudden cardiac death
• Allergy to moxifloxacin or the quinolone class of antibiotics