Effect on the Electrocardiographic QT Interval Corrected for Heart Rate (QTc) in Healthy Subjects

Randomized, Double-Blinded, Placebo-Controlled, Open Label Positive- Controlled, Four-Way Crossover Study of the Electrocardiographic Effects of BMS-708163 in Healthy Subjects

The purpose of this study is to determine the effect of BMS-708163 on the QTc interval (QT interval corrected for heart rate).

Inclusion Criteria:

• Body Mass Index (BMI) of 18 to 32 kg/m², inclusive.
• Women who are not of childbearing potential (ie, who are postmenopausal or surgically sterile) and men, ages 18 to 55
• Healthy subjects

Exclusion Criteria:

• History of cardiac arrhythmias or palpitations associated with presyncope or syncope, or history of unexplained syncope
• Sexually active fertile men not using effective birth control (double barrier) if their partners are WOCBP
• Women who are pregnant or breastfeeding
• History of allergy or intolerance to moxifloxacin or any member of the quinolone class of antimicrobial agents
• History of hypokalemia, history or family history of prolonged QT interval, or family history of sudden cardiac death at a young age
• Any clinically significant ECG abnormality
• History of seizure disorders
• History of drowning survival