The purpose of this research study is to determine if varying strengths of ethanol affect the drug level and safety profile of Vicodin® CR.

Inclusion Criteria:

• Males and females ages 19 to 55
• If female, must be of non-child bearing potential or practicing birth control
• Current alcohol users who are classified as moderate drinkers (defined as 7-21 drinks per week)

Exclusion Criteria:

• Intolerance towards ethanol
• Is allergic to or has a serious reaction to hydrocodone, other opioids, or acetaminophen
• Significant GI narrowing or abnormality with a potential to inhibit GI motility or tablet transport
• History of seizures or convulsions, head injury or other intracranial lesions, or a pre-existing increase in intracranial pressure
• Has any clinically significant abnormalities on physical examination, ECG, or laboratory values
• Treatment with any investigational drug within 30 days of administration of study drug in the Treatment Phase