Effects of Ethanol on Oxycodone Pharmacokinetics in Healthy Volunteers

An Open Label, Single Dose, Randomized, Two Way Crossover Study to Estimate Oxycodone Relative Bioavailability in Healthy Volunteers Following Administration of PF 00345439 Formulation K 40 Mg Under Fasting Conditions With 40% Ethanol Compared With Water

To Estimate Bioavailability Of 40 Mg Doses Of Pf-00345439 Formulation K Under Fasting Conditions with 40% Ethanol Compared with Water in Healthy Volunteers

Inclusion Criteria:

• Healthy volunteers
• History of moderate alcohol consumption
• Total body weight exceeding 64 kg

Exclusion Criteria:

• Evidence or history of clinically significant disease.
• Positive urine drug test
• History of alcoholism or heavy alcohol consumption