The purpose of this study is to check if bacterial and fungal flora exists in healthy paranasal sinuses, and whether it is identical to the flora of nasal cavity.

We plan to harvest tiny examples of maxillary sinus and nasal mucosa for tissue cultures during the orthognathic procedures involving maxillary remodeling.

Inclusion Criteria:

• Necessity of maxillary sinus opening during orthognathic surgery
• Negative history of chronic rhinitis or chronic sinusitis
• Informed concent

Exclusion Criteria:

• Recent(1 month or less before the operation) event of acute sinusitis or other disease leading to nasal discharge
• Recent(1 month or less before the operation) antibacterial or antifungal parenteral treatment

Healthy adults undergoing orthognatic procedure