A clinical study to evaluate the efficacy and safety of MK0633 in patients with Chronic Obstructive Pulmonary Disease (COPD).

Inclusion Criteria:

• Documented COPD defined by clinical history and spirometry, with symptoms including dyspnea, wheezing, chest tightness, cough, sputum production, or nocturnal awakening
• Male or postmenopausal females 40 -75 years of age

Exclusion Criteria:

• Impaired renal function
• History of chronic liver disease or persistent liver function test (LFT) abnormalities
• History of recent cardiovascular clinical event
• Evidence of another clinically significant, active pulmonary disorder such as bronchiectasis or asthma