A Study on the Effect of Kidney Disease on a Diabetes Medication (0431-008)

An Open- Label, 2 Part Study to Investigate the Pharmacokinetics, Safety, and Tolerability of MK0431(Sitagliptin Phosphate) in Patients With Varying Degrees of Renal Insufficiency

A study to evaluate the effect of kidney disease, from mild to severe disease, on a diabetes medication

Inclusion Criteria :

• Male and non-pregnant females with a clinical diagnosis of renal insufficiency with mild, moderate, severe or end stage renal disease on hemodialysis
• A body mass index of less than 40 kg per meter squared (body weight in kg divided by height in meters squared)
• Smokes less than 10 cigarettes/day

Exclusion Criteria :

• Patients with uncontrolled diabetes or uncontrolled congestive heart failure
• Patient has abnormal prestudy laboratory measurements including serum potassium or white blood counts
• Patient has systolic blood pressure below 100 mm Hg or above 180 mm Hg
• Patient has diastolic blood pressure less than 50 mm Hg systolic or above 100 mmHg