Safety and Effectiveness of tPA in Intra-abdominal Abscesses

Safety and Effectiveness of Local Instillation of tPA in the Management of Complex Intra-abdominal Fluid Collections: a Randomized, Double Blinded Controlled Clinical Trial

To determine if instillation of tissue plasminogen activator into a percutaneously drained intra-abdominal abscess cavity results in faster resolution of the abscess compared to normal standard of care.

On day 0 Subjects will have Tissue Plasminogen Activator injected into a drainage tube and allowed to dwell in the intra-abdominal abscess for one hour before allowing it to drain by gravity. This will be repeated on day 1 and 2.

Inclusion Criteria:

• Intrabdominal abscess

Exclusion Criteria:

• Hypersensitivity to tPA
• Recent stroke
• Uncontrolled htn
• Recent major hemorrhage
• Pregnancy