Effects of Optimized Antiplatelet Treatment After Percutaneous Coronary Intervention

Pilot Study of Personal Optimized Antiplatelet Treatment After Percutaneous Coronary Intervention in Patients With Acute Coronary Syndromes

Effects of dual antiplatelet therapy with aspirin and clopidogrel after percutaneous coronary intervention has been proven. However, patients with low response to those agents are reported be associated with adverse clinical outcomes. We suppose that optimized antiplatelet therapy for individual patients based on platelet function assay may improve long-term outcomes especially in patients with high risk of thrombosis. In this prospective randomized study, patients in control group all receive standard dual antiplatelet therapy, and patients in optimized group receive different antiplatelet therapy according to risk stratification.

Inclusion Criteria:

• non-ST-segment elevated acute coronary syndromes
• patients undergoing selective or emergent PCI

Exclusion Criteria:

• administration of clopidogrel or ticlopidine within 2 weeks
• ST-segment elevated myocardial infarction
• contraindications of antiplatelet therapy
• history of intracranial bleeding
• known bleeding disorders
• severe liver or kidney disease