The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of the administration of 2 different dose levels of Extended Release Hydrocodone/Acetaminophen with placebo over a 48 hour dosing period in patients who have had bunionectomy surgery, and to assess the safety of the drug for 7 days after patients are discharged from the hospital.

Inclusion Criteria:

• Male or female ages 18 to 65
• Females must be of non-childbearing potential or practicing birth control
• Subject is scheduled to undergo primary, unilateral first metatarsal bunionectomy surgery

Exclusion Criteria:

• Is allergic to or has a serious reaction to hydrocodone, or other opioids, acetaminophen, lidocaine or propofol, and/or similar drugs
• Has initiated corticosteroid therapy within the past month or is scheduled to receive any corticosteroid during the study
• Is associated with any currently ongoing research study