The purpose of this study is to evaluate the effectiveness (level of pain control) and safety of the administration of Extended Release Hydrocodone/Acetaminophen and Immediate Release Hydrocodone/Acetaminophen with placebo over a 12 hour dosing period in patients who have had a bunionectomy, and to assess the safety of the drug for 7 days after patients are discharged from the hospital.

Inclusion Criteria:

• Males and females ages 18 to 65
• Scheduled to undergo primary, unilateral, first metatarsal osteotomy (bunionectomy)
• Must meet specific pain intensity criteria on the morning after surgery
• Willing to remain at the study center 2 days following surgery
• If female, must be of non-child bearing potential or practicing birth control

Exclusion Criteria:

• Is allergic to or has a serious reaction to hydrocodone, hydromorphone, oxycodone, acetaminophen, ketorolac, lidocaine, bupivacaine, or mepivacaine
• Is allergic to or has a serious reaction to aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs)
• Has a history of or currently has any active seizure disorder
• Has a history of or any disease causing severe gastrointestinal narrowing or slowing down the gastrointestinal tract
• Has been diagnosed with cancer within the past 3 years
• Requires treatment with certain drugs for depression or psychiatric disorders
• Has specific clinically significant illnesses or laboratory abnormalities
• Received corticosteroid treatment or any investigational drug within a specific timeframe.