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The purpose of this clinical research study is to demonstrate the ability of Definity® enhanced versus unenhanced cardiac ultrasound to improve the accuracy and reproducibility of left ventricular ejection fraction (EF) when compared to magnetic resonance imaging (MRI).
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Definity® Vial for (Perflutren Lipid Microsphere) Injectable Suspension | Drug | The intervention for this study was that all patients received a slow bolus injection of diluted DEFINITY during the contrast-enhanced imaging study. |
| Measure | Description | Time Frame |
|---|---|---|
| Demonstrate the ability of Definity® enhanced versus unenhanced echocardiography to improve the accuracy of left ventricular ejection fraction when compared to cardiac magnetic resonance imaging (MRI) in a blinded assessment | Following the completion of patient enrollment when the images (ultrasound and MR) were evaluated independently by three blinded readers. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Veronica Lee, MD | Lantheus Medical Imaging | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Arizona | Tucson | Arizona | 85727 | United States | ||
| University of Chicago Medical Center |
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| Chicago |
| Illinois |
| 60637 |
| United States |
| Washington Hospital Center | Washington DC | Maryland | 20010 | United States |
| Saint Lukes Mid America Heart Institute | Kansas City | Missouri | 64111 | United States |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | United States |
| Duke University Medical Center | Durham | North Carolina | 27710 | United States |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | United States |
| Oregon Health & Science University | Portland | Oregon | 97239 | United States |
| University of Pittsburgh Medical Center | Pittsburgh | Pennsylvania | 15213 | United States |
| University of Texas Medical Branch | Galveston | Texas | 77555 | United States |