Abnormalities of B Lymphocytes During Systemic Lupus

Phenotypic Characteristics and Transcriptomas of B Lymphocytes During Non Active Systemic Lupus Erythematosus

Previous experimental data strongly suggest that B lymphocytes have intrinsic abnormalities during lupus in mice spontaneously affected by the disease. This study tries to define these abnormalities by looking at the gene expression profile of purified B lymphocytes from patients with non active systemic lupus , compared with the gene expression profile of purified B lymphocytes from healthy donnors.

Inclusion criteria:

• non active systemic lupus

Exclusion criteria:

• immunosuppressive drugs
• more than 10 mg of prednisone per day